Its important to have access to mental health care before and

during HCV treatment, so that psychiatric side effects can be

treated promptly and appropriately, if it becomes necessary.
Starting an antidepressant before going on HCV treatment can help
to prevent depression from interferon. Sometimes people need to try
several different antidepressants before finding one that is right for
them.
Antidepressants and other psychiatric medications have their own
side effects, so other experts think it is better to provide these drugs
only if and when people need them.
It is important to correctly diagnose and properly treat psychiatric
symptoms of HCV treatment.

Flulike symptoms
Flulike symptoms (fever, aches and pains, headache, chills, and
nausea) are common side effects of interferon.
Taking the pegylated interferon shot in the evening helps, as does a
low dose of acetaminophen and anti-nausea medication and/or
dronabinol (also called Marinol, a derivative of marijuana).
Drinking plenty of water helps to lessen flulike symptoms