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Itp Ajeng
Itp Ajeng
What is ITP
Immune / idiophatic
thrombocytopenic purpura (ITP) is a
bleeding disorder in which the blood
doesnt clot as it should, this is due
to the deficient of blood cell
fragments called platelet or
thrombocytes
Acute ITP
Chronic ITP
age
A peak incidence
between 2-5 years of
age
onset
Relatively acute
Relatively chronic
Degree of
hemorrhage
Relatively acute
Relatively mind
Course of desease
6 months
Months to years
Platelet count
Commonly 30,00080,000/mcL
Number of
megakaryocytes of
bonemarrow
Normal or increased
Increased markedly
Manifestations
Bleeding
(most important clinical manifestation of ITP
petechiae
ecchymoses
epistaxis (spontaneous bleeding from nose)
gingival bleeding
menorrhagia
Disabling fatigue
Proteinuria/ hematuria
Abdomonal pain
nausea, vomiting
fever
Diagnostic tests
Laboratory
o Platelets (often <20000-30000 / MCL) and normal
blood cells.
o Bleeding Time (BT, Bleeding Time) prolong
o The period of prothrombin (PT, Prothrombin
Time): normal
o Partial Prothrombin Time (PTT, Partial PT): normal
o Examination of peripheral blood deletion:
- Leukocytes, hemoglobin in normal circumstances
unless there is bleeding.
- Platelets greater (younger), there is no collection
of platelets
Anti D iv
the doseof anti D 50-75mg/kb/day
mechanisme of action of anti-D is the
destruction of red bloods cells of
rhesus D-positive that specifically
grated in the spleen