6

Dermatopathology

Hyper-/hypopigmentation
Increased/decreased melanin pigment

Interface
Generally refers to the dermoepidermal
junction

Kamino body
Dull pink to amphophilic basement
membrane material within the epidermis in a
Spitz nevus

bodies, then karyorrhexis resembles

dismembered ants and scattered ant heads)

Koilocytes
Keratinocytes with clear cytoplasm and
shrunken raisin-like pyknotic nuclei

LeishmanDonovan body
Intracytoplasmic collections of amastigotes in
leishmaniasis

Lentiginous epidermal hyperplasia

Karyorrhexis

Elongated bulbous rete

Fragmentation of neutrophils (leukocytoclasis)

(If neutrophils resemble ants with segmented

Lentiginous melanocytic growth

pattern
Proliferation predominantly along the dermal
epidermal junction

Leukocytoclasia
Fragmentation of neutrophils, also referred to
as leukocytoclasis or karyorrhexis

Lichenoid dermatitis
Interface dermatitis with destruction of
the basal layer and Civatte body formation
(Figure 1-7)

Lichenoid infiltrate
A band-like infiltrate, generally composed
predominantly of lymphocytes, located at the
dermoepidermal junction

Medlar body
Brown, round structure resembling
overlapping copper pennies
Divide by septation, resembling a hot-cross
bun

Figure 1-20 Kamino bodies, Spitz nevus

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Figure 1-21 Karyorrhexis, leukocytoclastic vasculitis

Figure 1-22 Leishman-Donovan bodies, leishmaniasis