Chapter

The basics: diagnostic terms, skin anatomy, and stains

Metachromasia

Pagetoid scatter

The property of staining a different color from

the stain itself (i.e., the purple color of mast cell
granules with the blue stain methylene blue)

Buckshot scatter of atypical cells within the

epidermis (Figure 1-26)

MichaelisGutman body
Intra- and extracellular calcified, concentric
circular structures, seen in malakoplakia

Palisading
Picket fence-like arrangement at the
periphery

Munro microabscess
Collection of neutrophils in the stratum
corneum, as seen in psoriasis

Necrobiosis
Pale-staining smudged necrotic collagen

Negri body
Inclusions within neurons seen in rabies
infection

Orthokeratosis
Increased thickness of the stratum corneum
without retained nuclei

Pagetoid cells

f0250
Figure 1-25 Necrobiosis, necrobiosis lipoidica

Large cells with abundant cytoplasm within

the epidermis

Figure 1-26 Pagetoid cells and pagetoid scatter, Pagets

disease
Figure 1-23 Medlar bodies, chromomycosis

Figure 1-24 Munro microabscess, psoriasis

Figure 1-27 Palisading, gout