Date

PRACTICAL-22
Aim :
A. Formula for hydrocarbon base:
Ingrediants

Quantity given
(gm)
Liquid paraffin 50
White paraffine 100
Glycerin
300
Cetostearyl
80
alcohol
Methyl paraben 3
Polysorbate
36
Glyceryl
20
monostearate
water
q.s.

Quantity taken Role

(gm)
ingredient
1.5
3
9
2.4

of

0.09
1.08
0.6
q.s.

Method of preparation:
1. Preparation of water phase
a. Purified water, polysorbate 60, and glycerine with agitation were added to
porcelain disc.
b. Contents were heated to 61C to 65C.
c. Methyl paraben was added and composition was mixed to dissolve
while maintaining temperature.

2. Preparation of oil phase

a. Liquid paraffin, cetostearyl alcohol, white petrolatum, glycerol
monostearate, and white beeswax were taken in porcelain disc and mixed
continuously while heating to 71C to 75C.

3. Mixing of phases
a. The mixture of step 2 is transferred to step while maintaining temperature
to 61-65C and mixture was allowed to cool gradually to room temperature.

4. Fill in appropriate container.

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Observation tables:
Formulation
Sr.
No.
1

Evaluation
parameters
Apperance
Colour
Texture
Odour

Effect on skin
Spreadability
Film formation
Washabality
Grisenees
Irritation/ cooling

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B. Formula for absorption base :
Ingredients
Methyl salicylate
Clove oil
Water
Menthol
Wool fat
White bees wax

Quantity
25 gm
0.25 ml
2.5 ml
5 gm
7.5 gm
10 gm

Role of ingredient

Method of preparation:
Oil phase was prepared by taking wool fat and white bees wax and clove oil in
one porcelain disc and heated to 60-65C.
Aqueous phase was prepared by taking water, menthol and methyl salicylate in
one porcelain disc and heated to 40C.
Then oil phase was added to aqueous phase with stirring and allowed to cool to
room temperature gradually.
Filled in appropriate container.

C. Formula for water miscible base:

D. Formula for water soluble base:
E. Evaluation parameters:
1. Appearance
i.
ii.
iii.

Color
Texture
Odour

2. Effect on skin
i.
ii.
iii.
iv.

Spreadability
Film formation
Washability
Greasiness

Comment:

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Reference:
1. Sarfaraz K. Niazi, Handbook of Pharmaceutical manufacturing
formulation, volume 4, second edition, informa health care, page no.
2.

109,190.