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    Dissolusion Calculasion

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    kjghlkdfjg
    This document contains data from a dissolution profile experiment measuring the concentration of metformin over time when administered via two different methods: wet granulation and direct compression. The data includes the concentration in micrograms per milliliter and total micrograms dissolved per 900ml at various time points. A linear trendline is fitted to the concentration data with an R2 value of 0.9977, indicating a strong linear relationship between concentration and time.

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    Dissolusion Calculasion

    Uploaded by

    kjghlkdfjg
    45 views11 pages
    This document contains data from a dissolution profile experiment measuring the concentration of metformin over time when administered via two different methods: wet granulation and direct compression. The data includes the concentration in micrograms per milliliter and total micrograms dissolved per 900ml at various time points. A linear trendline is fitted to the concentration data with an R2 value of 0.9977, indicating a strong linear relationship between concentration and time.

    Original Description:

    .

    Original Title

    DISSOLUSION CALCULASION

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    This document contains data from a dissolution profile experiment measuring the concentration of metformin over time when administered via two different methods: wet granulation and direct compression. The data includes the concentration in micrograms per milliliter and total micrograms dissolved per 900ml at various time points. A linear trendline is fitted to the concentration data with an R2 value of 0.9977, indicating a strong linear relationship between concentration and time.

    Copyright:

    © All Rights Reserved
    Download as XLSX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as xlsx, pdf, or txt
    45 views11 pages

    Dissolusion Calculasion

    Uploaded by

    kjghlkdfjg
    This document contains data from a dissolution profile experiment measuring the concentration of metformin over time when administered via two different methods: wet granulation and direct compression. The data includes the concentration in micrograms per milliliter and total micrograms dissolved per 900ml at various time points. A linear trendline is fitted to the concentration data with an R2 value of 0.9977, indicating a strong linear relationship between concentration and time.

    Copyright:

    © All Rights Reserved
    Download as XLSX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as xlsx, pdf, or txt
    of 11

    0

    10
    20
    30
    40
    50
    60

    time
    0
    10
    20
    30
    40
    50
    60
    70

    0
    0.1512
    0.3
    0.4122
    0.5999
    0.7412
    0.8612

    abs.
    0
    0.1981
    0.2932
    0.371
    0.452
    0.531
    0.599
    0.622

    f(x) = 0.0145125x + 0.002


    R = 0.9977454966

    conc(mcg/ml)
    0
    14.0071428571
    20.8
    26.3571428571
    32.1428571429
    37.7857142857
    42.6428571429
    44.2857142857

    conc. * dil. Factor


    0
    140.0714285714
    208
    263.5714285714
    321.4285714286
    377.8571428571
    426.4285714286
    442.8571428571

    conc(mcg/5ml)
    0
    700.3571428571
    1040
    1317.857142857
    1607.142857143
    1889.285714286
    2132.142857143
    2214.285714286

    Dissolution pr

    a) Metformin by wet granulation

    b) Metfor

    a) Metformin by wet granulation

    b) Metfor

    f(x) = 0.0145125x + 0.0025821429


    R = 0.9977454966

    Column B

    conc(mcg/900ml)
    0
    126064.28571429
    187200
    237214.28571429
    289285.71428572
    340071.42857143
    383785.71428572
    398571.42857143

    cum.conc(mcg/5ml)
    0
    0
    1740.3571428572
    2357.8571428572
    2925
    3496.4285714286
    4021.4285714286
    4346.4285714286

    Dissolution profile

    n by wet granulation

    b) Metformin by Direct Compression

    Linear (Column B)

    Total mcg/900ml
    0
    126064.285714286
    188940.357142857
    239572.142857143
    292210.714285714
    343567.857142857
    387807.142857143
    402917.857142857

    n by wet granulation

    b) Metformin by Direct Compression

    Chart Title

    Linear (Column B)

    Total mg/900ml
    0
    126.0642857143
    188.9403571429
    239.5721428571
    292.2107142857
    343.5678571429
    387.8071428571
    402.9178571429

    %DR
    0
    25.2128571429
    37.7880714286
    47.9144285714
    58.4421428571
    68.7135714286
    77.5614285714
    80.5835714286

    t Title

    time
    0
    10
    20
    30
    40
    50
    60
    70

    abs. conc(mcg/ml)
    conc. * dil. Factor
    conc(mcg/5ml)
    conc(mcg/900ml)
    0
    0
    0
    0
    0
    0.2132 15.08571 150.8571 754.2857 135771.4
    0.319
    22.64286 226.4286 1132.143 203785.7
    0.436
    31
    310
    1550
    279000
    0.521
    37.07143 370.7143 1853.571 333642.9
    0.598
    42.57143 425.7143 2128.571 383142.9
    0.629
    44.78571 447.8571 2239.286 403071.4
    0.656
    46.71429 467.1429 2335.714 420428.6

    cum.conc(mcg/5ml)
    0
    0
    1886.4285714286
    2682.1428571429
    3403.5714285714
    3982.1428571429
    4367.8571428572
    4575

    Total mcg/900ml Total mg/900ml %DR


    0
    0
    0
    135771.428571429 135.7714 27.15429
    205672.142857143 205.6721 41.13443
    281682.142857143 281.6821 56.33643
    337046.428571429 337.0464 67.40929
    387125
    387.125
    77.425
    407439.285714286 407.4393 81.48786
    425003.571428571 425.0036 85.00071

    643.75
    642.5
    643
    650
    644.5
    638
    642.6
    640
    640
    642.22
    643.2
    642.1
    648
    643.5
    643
    641.9
    643.9
    650
    650
    643
    12875.17
    643.7585

    0.7265
    -0.5235
    -0.0235
    6.9765
    1.4765
    -5.0235
    -0.4235
    -3.0235
    -3.0235
    -0.8035
    0.1765
    -0.9235
    4.9765
    0.4765
    -0.0235
    -1.1235
    0.8765
    6.9765
    6.9765
    -0.0235

    0.1129818739
    -0.0814122656
    -0.0036546098
    1.0849525717
    0.2296183576
    -0.7812311681
    -0.0658607345
    -0.4702005448
    -0.4702005448
    -0.1249565529
    0.0274484525
    -0.1436183903
    0.7739219484
    0.074103046
    -0.0036546098
    -0.1747214526
    0.1363091707
    1.0849525717
    1.0849525717
    -0.0036546098

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