PRACTICALAIM:

REQUIRMENTS: Mortar pestle, spatula, butter paper, sieves, tablet

punching machine, plastic bag,
Disintegration apparatus, etc.
REFERENCE :
FORMULA:
For Paracet
mul amol
atio (mg)
n

F1

125

Lact Star Starch MC

ose ch
powde C
(mg) pas r
te
activa
(10 ted
%
with
w/v water
)
(10%
w/v)
375 q.s -

F2

125

375

q.s

F3

125

375

q.s

5% -

F4

125

375

2%

F5

125

375

2%

PROCEDURE:
Wet granulation method:

SSG
(externa
l)
(PVP+w
ater)

SSG
Tal Mg
(Interna c
stear
l)
ate
(PVP+w
ater)

1
%
1
%
1
%
1
%
1
%

2%
2%
2%
2%
2%

Formulation F1: Paracetamol, lactose, starch-5% as inter granular

disintegrating agent were weighed accurately according to formula, mixed
throughly in mortar and starch paste (10%) was added drop wise to get damp mass.
Formulation F2: Here starch power activated with water was
added drop wise in formula to get damp mass.
Formulation F3: According to formula MCC and other ingredients
and starch paste (10%) was added drop wise to get damp mass.
Formulation F4: Paracetamol, lactose were weighed accurately according to
formula, mixed throughly in mortar and PVP(10%)+water was added drop wise to
get damp mass. SSG-2% as external granular disintegrating agent added.
Formulation F5: Paracetamol, lactose, SSG-2% as inter granular
disintegrating agent were weighed accurately according to formula, mixed
throughly in mortar and PVP(10%)+water was added drop wise to get damp mass.
This damp mass was passed through a sieve no:16 and the
obtained granules were dried in hot air oven at 60C.
The obtained dried granules were again passed through sieve no:
40.
For lubrication:
Dried granules were weighed. The yield was found (theoretical
and practical).
The required quantity of lubricants was calculated on the basis of
practical yield. The granules were tapped on 40# sieve and the
fines were collected. The fines were weighed (should not be more
than 15% w/w of granules).
Lubricant was mixed with fines by tumbling method.
The lubricated fines were mixed with the remaining granules by
tumbling method.
Formulation of tablets:

The granules of F1, F2, F3, F4 and F5 were compressed using

rotaty punch tablet machines the hardness of the tablets was
adjusted to optimum levels with required amount of compression
force.

DISINTEGRATION TIME STUDY:

The prepared tablets were put into disintegrating apparatus and
note the time till no palpable mass seen.
FORMULAT TIME
ION
(mins)
F1
F2
F3
F4
F5

EVALUATION PARAMETERS:
1. Disintegration time

RESULT:
PARAMETE F1
R
Disintegrati
on
Time (sec)
CONCLUSION:

F2

F3

F4

F5

RESULT: