Aim:

Requirement:
Reference:
Formula:
Ingrediants
Metformin
Lactose
Starch
Isopropyl alcohol
(IPA)
Talc
Magnesium
Stearate
Aerosil

Formula for one

tablet
500 mg
4.7 mg
4.5 mg
10 ml

Formula for 20
tablets
10 gm
0.094 gm
0.090 gm
0.2 gm

0.8 mg
5 mg

0.016 gm
0.1 gm

5 mg

0.1 gm

Procedure (wet granulation):

All the ingredients were weighed accurately.
Metformin and lactose were taken in mortar and pestle
and grinded together to have uniform mixing and obtain
fine powder.
10% of PVP solution of IPA was prepared and q.s was
added to the fine powder to obtain the lump mass.
Pass this lump mass through 10# sieve and collect
granules obtained.
The granules were collected on the paper and allowed to
dry in oven at 45C.
After drying the mass was passed through 20# sieve and
granules were retained on 40# sieve.
Talc, magnesium stearate and aerosil were mixed with
granule geometrically.
Fines obtained were weighed.
15% of fines were added to the dried granules and pack
edt in zip lock bag and punched into tablets using tablet
punching machine.
Tablets were then evaluated.

Evaluation parameters:
1.
2.
3.
4.

Weight variation
Hardness
Friability
Dissolution

1 .Observation table of weight variation

Sr.n
o.
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
Avg.

Weight of
tablets(x)
519
520
520
521
521
520
522
520
518
519
520
523
522
521
520
518
519
520
520
521

x-x

avg

2. Hardness of tablet:
3. Observation table of Friability
Initial weight of tablet (a):

x-x avg /x avg

*100

Final weight of tablet (b):

Weight loss: a-b
% weight loss: a-b/a*100
4. Observation table of Dissolution

Sr.n
o.

Time(mi
n.)

1
2
3
4
5
6
7

0
10
20
30
40
50
60

absorban Conc.p
ce
er ml.

Conc.i
n 900
ml

Cumulati %
ve conc. drug
releas
e