Cervical cancer

pathogenesis
MCQ
Dr. Oindi

Indicate true or false regarding

Human papillomaviruses
a) They are absolutely species specific and tissue specific
b) They infect and replicate in a fully differentiating
squamous epithelium only
c) HPV prevalence in squamous cell carcinoma 99.7%
d) In highgrade intraepithelial neoplasia and invasive
cancers, HPV-DNA is located extrachromosomally in
the nucleus
e) In benign lesions the viral DNA is integrated into the
host genome
f) E6 oncoprotein inhibits cycle through the inhibition of
pRB function
TTTFFF

 Indicate True or False as applicable

a)CIN usually starts at the
squamocolumnar junction (SCJ)
b) CIN is more likely to develop after
menopause
c)CIN is more likely to develop after
menarche and child birth
d)Use of oral contraceptive pills for a
short duration predispose one to
development of CIN
TFTF

The following statements are true

a) cervical cancer can be regarded as a sexual
transmitted disease
b) everyone who is infected with HPV will develop
cervical cancer
c) cytology together with HPV testing will detect all
cancers
d) Numerous studies regarding cofactors are
useless if there is no adjustment for HPV infection
e) the p53 pathway is the basis for cervical
carcinogenesis
TFFTF

State whether the following statements are True or

False
a) HPV infection of the cervix is a necessary
condition for the development of cervical cancer
b) All women infected with HPV are at risk for
cervical cancer
c) The prevalence of HPV infection varies with age
d) HPV DNA testing is useful in the triage of women
with low grade cytology
e) Current methods for the detection of HPV DNA
are reliable and reproducible
TFTFT

How can you explain a negative HPV test in a

patient with a high grade squamous
intraepithelial lesions (HSIL)?
a) The dysplasia is not related to HPV.
b) During the oncogenic transformation the circular
HPV genome was integrated in the human
genome at the binding site of the PCR-based HPV
test
c) The sensitivity of the test was unsufficient for
the HPV type involved
d) The diagnosis of high grade lesion was incorrect
FTTT

HPV DNA testing has clinical utility in the

following situations
a) Primary screening of women under 30
years of age
b) For the triage of women with equivocal
cytology (borderline or ascus)
c) For follow up of women post treatment
d) May be used for self sampling
e) Self sampling for HPV testing is
equivalent to clinician obtained sampling
FTTTF