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STROKE

Definisi ( WHO )
- Def. Neuro Fokal / Global
- Akut
- > 24 Jam / Meninggal
- Kelainan Pemb. Darah Otak

Klasifikasi Patologi :

Stroke Iskemik :
- Atherotrombotik
- Kardioemboli

Stroke Perdarahan :
- PIS
- PSA

Different Types of Stroke, 2000


Cerebral
Embolus
24%

Ischemic
Stroke
85%

TIA 3%

Cerebral
Thrombosis
61%

Intracerebral
Hemorrhage
Hemorrhagic
9%

Stroke
12%

Subarachnoid
Hemorrhage 3%

American Heart Association (AHA). Heart Disease and Stroke Statistics


2003 Update. 2003. Available at: http://www.americanheart.org/downloadable/heart/
10590179711482003HDSStatsBookREV7-03.pdf. Accessed October 13, 2003.

Klasifikasi Anatomi P. Darah

Sist. Karotis

Sist. Vertebrobasiler

FOKUS

Proses Atherotrombotik

Stroke KE

Stroke Usia Muda

Atherosklerosis

Atherosclerosis Process

Atherosclerosis Process

"response-to-injury" hypothesis : endothel Chronic injury


Monocyte, lipoprotein, platelet, lymphocyte, and smooth muscle cells
interactions.
The main "battleground" : the intima
Complex lipids + protein + carbohydrates + cell proliferation accumulation
in the intima .

Type I : chronic minimal injury, endothelial cells functional alterations w.o


significant morphologic changes caused by turbulence of blood flow.
Other factors : hypertension, hyperchol, vasoactive amines, viral, tobacco,
immunocomplexes.

Type II : denuding of endothel and superficial intima . result of toxic


released by macrophages in the intima + platelet deposition w/w.o
thrombus formation.

Type III : deep intima and medial damage + platelet aggregation + mural
thrombosis. Vascular injury seen following plaque rupture.

STROKE KE

Resource : jantung
Turbulensi darah
Kelainan : Irama ( AF) , anatomi ( dinding :
AMI, OMI, katup : MI MS )
Fungsi
Red Trombus : Eritrosit dominan, unstable
TH/ : Trombolitik ( rTPA )

STROKE KE
Khas :
Infark luas, Maximal at onset
Infark berdarah ( Akibat reperfusi )
- Hari 2 -4
- TTIK
- CT Scan : Salt & Pepper

STROKE USIA MUDA

Insidensi Meningkat

A VM ANOMALY VASCULER
B LOOD DYSCRASIA
C ARDIOVASKULER
D RUGS

STROKE USIA MUDA

AVM
- Nyeri kepala , satu sisi, berdenyut
- Bila pecah : Nyeri kepala hebat, KK,
TTIK, LB : Bloody
- D/ : MRA
- Th/ : Operatif

Stroke usia muda

Drugs : Amphetamine, Coccaine, Smoking,


Alcohol.

Life style

Economic Burden

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