Drug Name

Generic Name:
Diclofenac
Sodium
Brand Name:
Voltaren,
Fenac

Classification

Nonsteroidal
AntiInflammatory
drug

Mechanism of Action

Unknown, May
inhibit
prostaglandin
synthesis to
produce antiinflammatory,
Analgesic, and
antipyretic
effects.

Contraindication

Contraindicate
d in patient
hypersensitive
to drug and in
those with
hepatic
porphyria or
history of
Asthma,
urticarial, or
other allergic
reactions after
taking aspirin
or other
NSAIDSs.
Drug isnt
recommended
for using
during late
pregnancy or
breast- feeding

Adverse Effect

CNS: Anxiety ,
depression,
dizziness,
drowsiness,
insomnia, irritability,
headache,
CV: heart failure,
hypertension,
edema , fluid
retention
EENT : tinnitus,
laryngeal edema,
swelling of the lips
and tongue, blurred
vision, eye pain,
night blindness,
epistaxis, reversible
hearing loss.

GI: abdominal pain

or cramps, diarrhea,
Use cautiously indigestion, nausea,
in patients
abdominal
with history of distention,

Nursing
Consideration
.Because
NSAIDS impair
the synthesis of
renal
prostaglandins,
they can
decrease renal
blood flow and
lead to
reversible renal
impairment,
especially in
patients with
renal or heart
failure or liver
dysfunction, in
elderly patients
and in those
taking diuretics.
Monitor these
patients closely.
Liver function
test values may
increase during
therapy,

peptic ulcer
disease ,
hypertension,
fluid retention
Or impaired
renal function.

flatulence, taste
disorder peptic
ulceration, bleeding
melena.

Monitor
transaminase
especially ALT
levels
periodically in
patients
undergoing
long-term
therapy. Make
first
transaminase
measurement no
later than 8
weeks after
therapy begins.
Serious GI
toxicity
including peptic
ulcer and
bleeding can
occur in
patients taking
NSAIDS
despite lack of
symptoms