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  • Pharmacology of Amlodipine

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    RajDarvelGill
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    Amlodipine is a dihydropyridine calcium channel blocker that blocks L-type calcium channels, inhibiting the inward passage of calcium ions. It causes a substantial drop in blood pressure and reflex tachycardia. Amlodipine has high oral bioavailability of 65-90% and a long half-life of 30-50 hours. Common side effects include headache, flushing, peripheral edema, and palpitations, and hypotension may be exacerbated if combined with other blood pressure lowering drugs.

    Original Description:

    Calcium channel antagonist

    Original Title

    Amlodipine

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    Amlodipine is a dihydropyridine calcium channel blocker that blocks L-type calcium channels, inhibiting the inward passage of calcium ions. It causes a substantial drop in blood pressure and reflex tachycardia. Amlodipine has high oral bioavailability of 65-90% and a long half-life of 30-50 hours. Common side effects include headache, flushing, peripheral edema, and palpitations, and hypotension may be exacerbated if combined with other blood pressure lowering drugs.

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    15 views6 pages

    Pharmacology of Amlodipine

    Uploaded by

    RajDarvelGill
    Amlodipine is a dihydropyridine calcium channel blocker that blocks L-type calcium channels, inhibiting the inward passage of calcium ions. It causes a substantial drop in blood pressure and reflex tachycardia. Amlodipine has high oral bioavailability of 65-90% and a long half-life of 30-50 hours. Common side effects include headache, flushing, peripheral edema, and palpitations, and hypotension may be exacerbated if combined with other blood pressure lowering drugs.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as pptx, pdf, or txt
    of 6

    Pharmacology of

    Amlodipine

    MOA
    Dihydropyridine calcium channel
    blocker
    Blocks L-type calcium channels and
    inhibits inward passage of calcium
    ions through these channels
    Binds to a site on 1 subunit

    Causes substantial fall in BP and


    reflex tachycardia

    Pharmacokinetics
    Oral Bioavailability: 65-90%
    Half-life: 30-50 hours

    Adverse Effects

    Headache
    Flushing
    Peripheral oedema
    Palpitations

    Interactions
    Hypotension may be exacerbated if
    CCB are administered with other BP
    lowering drugs (e.g. beta blockers)

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