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  • Letter To The Editors: Bovine Leukemia Virus in Human Breast Tissues (Breast Cancer As Viral Disease?)

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    Elisabeth Rieping (1950 - 2009)
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    BLV is a potential causal agent for human breast cancer. BLV induces monocytes to form giant cells, which can develop into osteoclasts that are physiologically involved in bone resorption and breast cancer metastasis to bone. BLV is also related to HTLV-1, which causes acute T-cell leukemia and is associated with hypercalcemia as is breast cancer. While MMTV does not typically cause bone metastases in mice, traces of retroviruses similar but not identical to MMTV are often found in human breast cancer tissues, making BLV a better candidate for involvement than MMTV.

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    Leserinnenbrief / Breast Cancer Research v. 23.03.2006

    Original Title

    Letter to the Editors: Bovine Leukemia Virus in Human Breast Tissues [Breast Cancer as Viral Disease?]

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    BLV is a potential causal agent for human breast cancer. BLV induces monocytes to form giant cells, which can develop into osteoclasts that are physiologically involved in bone resorption and breast cancer metastasis to bone. BLV is also related to HTLV-1, which causes acute T-cell leukemia and is associated with hypercalcemia as is breast cancer. While MMTV does not typically cause bone metastases in mice, traces of retroviruses similar but not identical to MMTV are often found in human breast cancer tissues, making BLV a better candidate for involvement than MMTV.

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    42 views1 page

    Letter To The Editors: Bovine Leukemia Virus in Human Breast Tissues (Breast Cancer As Viral Disease?)

    Uploaded by

    Elisabeth Rieping (1950 - 2009)
    BLV is a potential causal agent for human breast cancer. BLV induces monocytes to form giant cells, which can develop into osteoclasts that are physiologically involved in bone resorption and breast cancer metastasis to bone. BLV is also related to HTLV-1, which causes acute T-cell leukemia and is associated with hypercalcemia as is breast cancer. While MMTV does not typically cause bone metastases in mice, traces of retroviruses similar but not identical to MMTV are often found in human breast cancer tissues, making BLV a better candidate for involvement than MMTV.

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    © All Rights Reserved
    Download as DOC, PDF, TXT or read online from Scribd
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    of 1

    Bovine leukemia virus in human breast tissues

    GC Buehring, KY Choi and HM Jensen

    from 23rd Congress of the International Association for Breast Cancer Research
    Düsseldorf, Germany. 13–16 June 2001

    Breast Cancer Res 2001, 3(Suppl 1):A14doi:10.1186/bcr338

    BLV as an agent involved in Breast Cancer

    Elisabeth Rieping (23 March 2006) www.erieping.de

    There are some additional features of BLV which qualify it as a causal agent for breast cancer: It induces monocytes to form giant cells.

    The osteoclasts physiologically active in bone resorption and during breast cancer metastasis develop from monocytes, too. Bone metastasis is an
    important feature of human, feline and canine breast cancer. All three species are frequently raised with bovine milk, although neither physians nor
    vets propagate it.

    HTLV-1 the close relative of BLV is found in acut T-cell leukemia ATL. A disease for which hypercalcemia is as typical as for breast cancer.

    MMTV induced tumors in mice rarely metastasize and they do not not show bone metastases.

    Traces of an MMTV like, not identical retrovirus are often found in human breast cancer. BLV is not identical. That would make it a better
    candidate to fit with these traces than MMTV itself.

    Elisabeth Rieping, Cologne

    BMC

    Competing interests: none, online: http://breast-cancer-research.com/content/3/S1/A14/comments

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