Data pengamatan

Pustaka
100 g asam
mefenamat
ditimbang
Dilarutkan dengan
etanol 95%
(dinetralisasi dengan
fenol red TS dengan
0.1 mol/l NaOH,
dipanaskan)
NaOH dibakukan
dahulu dengan asam
oksalat 0.1 N, 10 ml

Larutan sampel
didinginkan dan
dititrasi dengan 0,1
mol/l NaOH VS

Perhitungan kadar
as. mefenamat

Pengamatan
Asam mefenamat
ditimbang dengan berat
100.9 g; 100.7 g dan 100. 8
g
Asam mefenamat larut

Pembakuan NaOH (1)

V 1 NaOH = 10.6 ml
V1 x N1= V2 x N2
10.6 x N = 10 x 0.1
NNaOH(1) = 0.094 N
Pembakuan NaOH (2)
V 2 NaOH = 11.2 ml
V1 x N1= V2 x N2
11.2 x N = 10 x 0.1
NNaOH(2) = 0.089 N
Pembakuan NaOH (3)
V 3 NaOH = 10.3 ml
V1 x N1= V2 x N2
10.3 x N = 10 x 0.1
NNaOH(3) = 0.097 N
NNaOH rata = 0.093 N
Blanko etanol 0,2 ml
Titrasi as. Mefenamat (1) =
4,4 ml
Titrasi as. Mefenamat (2) =
4,1 ml
Titrasi as. Mefenamat (3) =
4,3 ml
Kadar asam mefenamat (1)
= (4.4 ml 0.2 ml) x 22.44
mg
= 94.248 mg/20 ml
Kadar asam mefenamat (2)
= (4.1 ml 0.2 ml) x 22.44
mg
= 87.516 mg/20 ml
Kadar asam mefenamat (3)
= (4.3 ml 0.2 ml) x 22.44
mg
= 92.004 mg/20 ml
Kadar rata = 91.256

Kriteria

British
Pharmacopoeia
1 ml 0,1 N NaOH :
24.13 mg
Nyata
1 ml 0.093 N
NaOH : 22.44 mg
Tidak sesuai
literatur

mg/20 ml