Ebola Virus Disease

Ebola, previously known as Ebola hemorrhagic fever, is a rare and deadly disease caused by
infection with one of the Ebola virus strains. Ebola can cause disease in humans and nonhuman
primates (monkeys, gorillas, and chimpanzees).
Ebola is caused by infection with a virus of the family Filoviridae, genus Ebolavirus. There are five
identified Ebola virus species, four of which are known to cause disease in humans: Ebola virus
(Zaire ebolavirus); Sudan virus (Sudan ebolavirus); Ta Forest virus (Ta Forest ebolavirus, formerly Cte
dIvoire ebolavirus); and Bundibugyo virus (Bundibugyo ebolavirus). The fifth, Reston virus (Reston
ebolavirus), has caused disease in nonhuman primates, but not in humans.
Ebola viruses are found in several African countries. Ebola was first discovered in 1976 near the
Ebola River in what is now the Democratic Republic of the Congo. Since then, outbreaks have
appeared sporadically in Africa.
The natural reservoir host of Ebola virus remains unknown. However, on the basis of evidence and
the nature of similar viruses, researchers believe that the virus is animal-borne and that bats are the
most likely reservoir. Four of the five virus strains occur in an animal host native to Africa.

Symptoms of Ebola include

Fever

Severe headache

Muscle pain

Weakness

Fatigue

Diarrhea

Vomiting

Abdominal (stomach) pain

Unexplained hemorrhage (bleeding or bruising)

Symptoms may appear anywhere from 2 to 21 days after exposure to Ebola, but the average is 8 to
10 days.
Recovery from Ebola depends on good supportive clinical care and the patients immune response.
People who recover from Ebola infection develop antibodies that last for at least 10 years.

Transmission
When an infection occurs in humans, the virus can be spread to others through direct contact
(through broken skin or mucous membranes in, for example, the eyes, nose, or mouth) with

blood or body fluids (including but not limited to urine, saliva, sweat, feces, vomit, breast milk,
and semen) of a person who is sick with Ebola

objects (like needles and syringes) that have been contaminated with the virus

infected fruit bats or primates (apes and monkeys)

Diagnosis
Diagnosing Ebola in a person who has been infected for only a few days is difficult because the early
symptoms, such as fever, are nonspecific to Ebola infection and often are seen in patients with more
common diseases, such as malaria and typhoid fever.
However, if a person has the early symptoms(http://www.cdc.gov/vhf/ebola/symptoms/index.html) of
Ebola and has had contact with the blood or body fluids of a person sick with Ebola; contact with
objects that have been contaminated with the blood or body fluids of a person sick with Ebola; or
contact with infected animals, they should be isolated and public health professionals notified.
Samples from the patient can then be collected and tested to confirm infection.

Laboratory tests used in diagnosis include:

Timeline of Infection

Diagnostic tests available

Within a few days after symptoms begin

*Antigen-capture enzyme-linked
immunosorbent assay (ELISA) testing
*IgM ELISA
*Polymerase chain reaction (PCR)
*Virus isolation
Later in disease course or after recovery

IgM and IgG antibodies

Retrospectively in deceased patients

Immunohistochemistry testing
PCR
Virus isolation

Prevention
There is no FDA-approved vaccine available for Ebola.
If you travel to or are in an area affected by an Ebola outbreak, make sure to do the following:

Practice careful hygiene. For example, wash your hands with soap and water or an alcoholbased hand sanitizer and avoid contact with blood and body fluids.

Do not handle items that may have come in contact with an infected persons blood or body
fluids (such as clothes, bedding, needles, and medical equipment).

Avoid funeral or burial rituals that require handling the body of someone who has died from
Ebola.

Avoid contact with bats and nonhuman primates or blood, fluids, and raw meat prepared from
these animals.

Avoid facilities in West Africa where Ebola patients are being treated. The U.S. embassy or
consulate is often able to provide advice on facilities.

After you return, monitor your health for 21 days and seek medical care immediately if you
develop symptoms of Ebola(http://www.cdc.gov/vhf/ebola/symptoms/index.html).
Healthcare workers who may be exposed to people with Ebola should follow these steps:

Wear appropriate personal protective equipment (PPE).

Practice proper infection control and sterilization measures. For more information, see
Information for Healthcare Workers and Settings(http://www.cdc.gov/vhf/ebola/hcp/index.html).

Isolate patients with Ebola from other patients.

Avoid direct, unprotected contact with the bodies of people who have died from Ebola.

Notify health officials if you have had direct contact with the blood or body fluids, such as but
not limited to, feces, saliva, urine, vomit, and semen of a person who is sick with Ebola. The virus
can enter the body through broken skin or unprotected mucous membranes in, for example, the
eyes, nose, or mouth.

Recommended Personal Protective Equipment

1. PAPR or N95 respirator
A PAPR with a full face shield, helmet, or headpiece. Any reusable helmet or headpiece must
be covered with a single-use (disposable) hood that extends to the shoulders and fully covers
the neck and is compatible with the selected PAPR. The facility should follow manufacturers
instructions for decontamination of all reusable components and, based upon those
instructions, develop facility protocols that include the designation of responsible personnel

who assure that the equipment is appropriately reprocessed and that batteries are fully
charged before reuse.

Single-use (disposable) N95 respirator in combination with single-use (disposable) surgical

hood extending to shoulders and single-use (disposable) full face shield.** If N95 respirators
are used instead of PAPRs, careful observation is required to ensure healthcare workers are
not inadvertently touching their faces under the face shield during patient care.

2. Single-use (disposable) fluid-resistant or impermeable gown that extends to at least mid-calf

or coverall without integrated hood. Coveralls with or without integrated socks are
acceptable.
3. Single-use (disposable) nitrile examination gloves with extended cuffs. Two pairs of gloves
should be worn. At a minimum, outer gloves should have extended cuffs.
4. Single-use (disposable), fluid-resistant or impermeable boot covers that extend to at least
mid-calf or single-use (disposable) shoe covers. Boot and shoe covers should allow for ease
of movement and not present a slip hazard to the worker.
5. Single-use (disposable), fluid-resistant or impermeable apron that covers the torso to the
level of the mid-calf should be used if Ebola patients have vomiting or diarrhea. An apron
provides additional protection against exposure of the front of the body to body fluids or
excrement. If a PAPR will be worn, consider selecting an apron that ties behind the neck to
facilitate easier removal during the doffing procedure.

Treatment
No FDA-approved vaccine or medicine (e.g., antiviral drug) is available for Ebola.
Symptoms of Ebola and complications are treated as they appear. The following basic interventions,
when used early, can significantly improve the chances of survival:

Providing intravenous fluids (IV) and balancing electrolytes (body salts).

Maintaining oxygen status and blood pressure.

Treating other infections if they occur.

Experimental vaccines and treatments for Ebola are under development, but they have not yet been
fully tested for safety or effectiveness.
Recovery from Ebola depends on good supportive care and the patients immune response. People
who recover from Ebola infection develop antibodies that last for at least 10 years, possibly longer. It
is not known if people who recover are immune for life or if they can become infected with a different
species of Ebola. Some people who have recovered from Ebola have developed long-term
complications, such as joint and vision problems.