Rna Virus Rna Virus

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RNA VIRUS

Paramyxovirus
Envelope has HN and
specialized F spikes that
initiate cell-to-cell fusion.
Fusion with neighboring cells
syncytium or multinucleate
giant cells form
o Mumps
Epidemic parotitis;
self-limited,
associated with
painful swelling of
parotid salivary
glands, muscle pain
and malaise
Usually
uncomplicated
invasion of other
organs; in 20-30% of
infected adult males,
epididymis and
testes become
infected
o Measles
Morbillivirus
Also known as red
measles and rubeola

Different from
German measles
Sore throat, dry
cough, headache,
conjunctivitis,
lymphadenitis, fever,
Koplik spots,
rash

Rhabdovirus family
o Rabies
Enveloped, bulletshaped virions
Slow, progressive
zoonotic disease
Dog bites
multiplies at site
enters nerve endings
ganglia spinal
cord brain
Prodromal phase ->
Furious phase ->

Dumb phase ->


coma phase
Keyword :
Cerebral
inclusion
bodies
called Negri
bodies

Togavirus
o Rubella / German
Measles
ssRNA with a
loose envelope
Postnatal rubella
malaise, fever, sore
throat,
lymphadenopathy,
rash
Congenital rubella
infection during 1st
trimester most likely
to induce
miscarriage or
multiple defects

such as cardiac
abnormalities, ocular
lesions, deafness,
mental and physical
retardation
Lab : IGM + IGG
rubella virus

Nonenveloped Nonsegmented
ssRNA Viruses
o Picornaviruses
Poliovirus
naked
capsid;
resistant to
acid, bile,
and
detergents;
can survive
stomach
acids when
ingested
fecal-oral
route
fever,
headache,
nausea, sore
throat, and
myalgia
muscle pain
and spasm,
meningeal
inflammation
, and vague
hypersensiti
vity
Invasion of
motor
neurons
causes
flaccid
paralysis

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