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Therapy

Emergency

No further
workup

Hypokalemi
a
Serum K+ <3.5
mmol/L

Treat
accordingly

Treat according
and reevaluate

Clear evidence
of low intake

Pseudohypokale
mia

History, PE, and


basic laboratory
tests

Clear evidence
of intracellular
shift
Insulin excess
Beta-adrenergic
agonists
FHPP
Hyperthyroidism
Barium intoxication

Urine K

<15 mmol/day
OR <15 mmol/g
Cr

>15 mmol/day
OR >15 mmol/g
Cr

Extrarenal loss/
remote renal
loss

Renal loss

Acid-base
status

TTKG

Metabolic
Acidosis
Metabolic
acidosis
GI K+ loss

Normal
Profuse
sweating

Remote
diuretic use
Remote
vomiting or
stomach
drainage
Profuse
sweating

>4

distal
secretion

Low OR normal

<2
History, PE, and
basic laboratory
tests

tubular flow
Osmotic
diuresis

High

Variable

Acid-Base
status

Nonreabsorbable
anions other
than HCO3Hippurate
Penicillins

Metabolic
Acidosis

Metabolic
Alkalosis

Proximal RTA
Distal RTA
DKA
Ampothericin
B
Acetazolamide

Urine Cl(mmol/L)

>20

<10

Urine Ca/Cr
(molar ratio)

>0.20

<0.15

Loop diuretic
Bartters
syndrome

Thiazide
diuretic
Gitelmans
syndrome

>4

distal
secretion

Low OR normal

<2
History, PE, and
basic laboratory
tests

tubular flow
Osmotic
diuresis

High

Aldosterone

High

Low

Renin

Cortisol

High
RAS
RST
Malignant
HPN

Low

PA
FH-I

High

Normal

Cushings
Syndrome

Liddles
syndrome
Licorice
SAME

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