Cisplatin

Cisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer,
germ cell tumors, lymphoma, and ovarian cancer. While it is often considered an alkylating agent, it
contains no alkyls groups and does not instigate alkylating reactions, so it is properly designated as an
alkylating-like drug. Cisplatin is platinum-based and was the first medicine developed in that drug class.
Other drugs in this class include carboplatin, a drug with fewer and less severe side effects introduced in
the 1980s, and oxaliplatin, a drug which is part of the FOLFOX treatment for colorectal cancer. The other
names for cisplatin are DDP, cisplatinum, and cis-diamminedichloridoplatinum(II) (CDDP).
Cisplatin was actually first created in the mid 19th Century and is also known as Peyrone's chloride. (The
disoverer was Michel Peyrone.) It wasn't until the 1960s that scientists started getting interested in its
biological effects, and cisplatin went ito clinical trials for cancer therapy in 1971. By the late 1970s it was
already widely used and is still used today despite the many newer chemotherapy drugs developed over
the past decades.
Cisplatin is off-patent. That means no company has the exclusive right to its manufacture and any credible
drug company can make it (subject to government-approved safety regulations.) Bristol-Myers
Squibb settled with the Federal Trade Commission in 2003 over charges it engaged in anti-competitive
practices to keep the price of cisplatin high. Bristol-Myers Squibb sells Cisplatin under the brand name
Platinol.
The Chemical Abstract Registry (CAS) number is 15663-27-1.). The chemical forumla is Pt(NH3)2Cl2.
Molecular weith is 300.045. Cisplatin is soluble in water and delivered to the body in aqueous form.

The Penicillin of Cancer

Cisplatin is called the penicillin of cancer because it is used so widely and it was the first big
chemotherapy drug. Cisplatin also plays an interesting role in the history of chemistry. First synthesized in
the 1800s, long before anyone thought of using it against cancer, cisplatin is a target compound chemists
use to prove their moxie in inorganic synthesis. The shape and symbols of the molecule as represented in
that discipline's iconography is aesthetically pleasing which is another reason people like to talk about
cisplatin.
Cisplatin is a simple molecule only 11 atoms. Medicinal chemists are known to exclaim mon dieu! What
a small molecule! It's certainly different from the big biologics being introduced to the oncologist's toolbox
in recent years.
New chemotherapy drugs have arrived on the scene over the past few decades, but cisplatin still finds wide
use. Even when it is not the only or main drug given the the cancer patient, it can be a valuable part of a
combination chemotherapy regimen. Look at the regimens given to patients an you will often see cisplatin
as one of the drugs.
Even with the advent of the so-called targeted therapies in the past ten years, cisplatin use remains strong.
It's poisonous, of course, but that doesn't mean it isn't useful in the treatment of disease under the direction
of a physician. The side effects can be serious the vary from patient to patient of course but hundreds
of thousands of people have been given cisplatin and the medical establishment has learned how to deal
with it.

At the molecular level

The way that cisplatin operates is by forming a platinum complex inside of a cell which binds to DNA and
cross-links DNA. When DNA is cross-linked in this manner, it causes the cells to undergo apoptosis, or
systematic cell death. One of the methods it uses causes apoptosis through cross-linking is by damaging
the DNA so that the repair mechanisms for DNA are activated, and once the repair mechanisms are
activated and the cells are found to not be salvageable, the death of those cells is triggered instead.
Cisplatin is frequently given as part of a combination chemotherapy regimen with other drugs. And even
though it is an "old" drug as chemotherapy agents go (having been used for decades), it continues to find
uses, especially as it is synergistic with other agents. For instance, a study recently showed the monoclonal
antibody Erbitux (cetuximab) given with cisplatin is effective in patients with head and neck cancers