Bone osteoid (35%), mineral component (65%)

Osteoid type 1 collagen, proteins, glycosaminoglycans

Osteoblasts osteopontin/osteocalcin mineralize bone and ca
homeostasis (sensitive marker of osteoblast activity)
Osteoblasts surrounded by organic matrix = osteocytes
mechanotransduction (communicate via canaliculi gap
junctions)
Osteoblasts on cell surface flattened and quiescent bone
lining cells
Osteoclasts derived from hematopoietic stem cell lineage
stimulated by MCSF, IL1, TNF

Woven bone is weak and laid down by osteoblasts initially and is

replaced by organized lamellar bone
Endochondral ossification bone replaces cartilage (from
chondrocytes mesenchymal stem cells)