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    Chemical Reaction Engineering

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    PrincessAnnaTasha
    1) The document describes the production of lysine through a fermentation and downstream purification process. Key steps include fermentation at 35°C and pH 7.2, centrifugation at 30°C, ion exchange at 30°C and pH 9.59, and crystallization at 100°C. 2) Operating conditions like temperature, pH and pressure are provided for each major step. Calculations around sizing the fermenter, residence time, and reaction kinetics are also described. 3) An inlet and outlet mass and molar flow summary table is presented, tracking key components like glucose, lysine, glutamate, water, carbon dioxide and urea through the process.

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    Chemical Reaction Engineering

    Uploaded by

    PrincessAnnaTasha
    15 views4 pages
    1) The document describes the production of lysine through a fermentation and downstream purification process. Key steps include fermentation at 35°C and pH 7.2, centrifugation at 30°C, ion exchange at 30°C and pH 9.59, and crystallization at 100°C. 2) Operating conditions like temperature, pH and pressure are provided for each major step. Calculations around sizing the fermenter, residence time, and reaction kinetics are also described. 3) An inlet and outlet mass and molar flow summary table is presented, tracking key components like glucose, lysine, glutamate, water, carbon dioxide and urea through the process.

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    1) The document describes the production of lysine through a fermentation and downstream purification process. Key steps include fermentation at 35°C and pH 7.2, centrifugation at 30°C, ion exchange at 30°C and pH 9.59, and crystallization at 100°C. 2) Operating conditions like temperature, pH and pressure are provided for each major step. Calculations around sizing the fermenter, residence time, and reaction kinetics are also described. 3) An inlet and outlet mass and molar flow summary table is presented, tracking key components like glucose, lysine, glutamate, water, carbon dioxide and urea through the process.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    Download as pptx, pdf, or txt
    15 views4 pages

    Chemical Reaction Engineering

    Uploaded by

    PrincessAnnaTasha
    1) The document describes the production of lysine through a fermentation and downstream purification process. Key steps include fermentation at 35°C and pH 7.2, centrifugation at 30°C, ion exchange at 30°C and pH 9.59, and crystallization at 100°C. 2) Operating conditions like temperature, pH and pressure are provided for each major step. Calculations around sizing the fermenter, residence time, and reaction kinetics are also described. 3) An inlet and outlet mass and molar flow summary table is presented, tracking key components like glucose, lysine, glutamate, water, carbon dioxide and urea through the process.

    Copyright:

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    of 4

    CHEMICAL REACTION ENGINEERING

    (PRODUCTION OF LYSINE)
    REACTOR SELECTION

    OPERATING CONDITION
    Process

    Temperatur

    pH

    Pressure

    e (C)

    (atm)

    Fermentation

    35

    7.2

    Centrifugation

    30

    1-3

    Ion exchange

    30

    Crystallizer

    100

    9.59

    CALCULATION
    1

    Size of fermenter

    Actual size of fermenter =


    =

    Residence time

    Rate law

    Activation energy

    = =1

    -=
    - = (mol/dm3.s) ( )

    THE SUMMARY TABLE OF INLET AND OUTLET STREAM


    Molecule

    Inlet

    Outlet

    Glucose

    Mole
    Mole (mole)
    (mole)

    Mass
    Mass (kg)
    (kg)
    1028.285

    Mole
    Mole (mole)
    (mole)
    -

    Mass(kg)
    Mass(kg)
    -

    205.653
    205.653

    --

    --

    616.162
    616.162

    27 665.405
    27 665.405

    442.646
    442.646

    Lysine
    Lysine
    Glutamate
    Glutamate
    Water

    38 510.13
    38 510.13
    (1 0844.725
    (1 0844.725
    reacted)
    reacted)
    --

    --

    2 283.10
    2 283.10
    22 283.10
    283.10

    333.333
    333.333
    335.913
    335.913
    369.862

    CarbonDioxide
    CarbonDioxide

    --

    --

    12
    12 557.05
    557.05

    552.636
    552.636

    Urea
    Urea
    Oxygen
    Oxygen

    Stoichiometry
    C6H12O6 + CH4N2O + O2
    Glucose + Urea + Oxygen

    Lysine + Glutamate + Water + Carbon Dioxide

    Let,

    A+ B+C
    Species

    Symbol

    A
    A
    B
    B

    D + E + 9F + G

    ExampleofStoichiometricTableforBatchSystem
    Initial
    Change
    Remaining
    (mol)

    C6H12O6
    C6H12O6
    CH4N2O
    CH4N2O

    C6H14N2O2 + C5H4NO4 + 9H2O + CO2

    NAO
    NAO
    NBO
    NBO

    (mol)

    Concentration

    (mol)

    NAO X

    NA = NAO (1 X )

    CA = CAO (1 X )

    ( ) NAO X

    NB = NBO NAO X

    CB = CAO
    X B)

    NAO X

    =NAO X )
    B

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