Skin Pigmentation

Melanin in the Melanocyte Cells

Eumelanin Black/Brown Pigment
Pheomelanin Red/Yellow Pigment
Response to UV Radiation
Pigmented Cells
Resistant to Damage by Sun
Protected From Melanin Antioxidants
Unpigmented Cells
Sensitive to Sunlight Damage
Protected by Glutathione/Selenomethionine
Antioxidants

DEPIGMENTATION Properties of
Glutathione/Selenium

Protect Skin from UV Radiation which generate free

radicals that cause skin damage and hyperpigmentation

GSH redirects synthesis to the light (Pheomelanin) instead

of the dark (Eumelanin)

Inhibits enzyme tyrosinase that synthesizes dark melanins

Skin Cells become more resistant to UV exposure

(Brigarti, 2003)
(Burke, 1997)

Skin Brightening
Thione Complex lozenges with:
Glutathione & Selenomethionine
Plus Antioxidant Vitamins C & E
And the Glutathione Depigmenting Enzymes
A complement to the Skin Brightening Products
Free Radical Scavenging Functions to Reduce UV
Radiation to the Skin
Works From Within To The Skin

Melasma
Blotchy Hyper-pigmentation of Face
Associated with Pregnancy
Topical Therapy
Hydroquinone,
Retinoic Acid
Thione Complex
Oral Therapy with Glutathione/Selenium
Reduces UV Radiation Impact on Affected Skin
Induces Glutathione Enzymes
Promotes Synthesis of Clear Melanin
Inhibits Tyrosinase Enzyme that Makes Dark Melanin

The Aging Skin

Chrono-aging
Sagging Skin
Photo-aging
Wrinkles and Pigmented Lesions
Ultraviolet Radiation
Acute: Sunburn
Chronic: Oxidative Damage
Pre-malignant Lesions
(Keratosis, Moles)
Malignancy
Squamous/Basal Cells
Malignant Melanoma

Influence of Glutathione Levels in

Melanin Synthesis
Pathways to Melanin Synthesis
High GSH

Low GSH

Eumelanin
(Dark Pigment)

Eumelanin
(Dark Pigment)

Conclusion:

High GSH levels influence pathway toward the production of greater

amounts of clear pigment (Pheomelanin) in skin cells