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Brain Tumor: Anwar Wardy W
Brain Tumor: Anwar Wardy W
Anwar Wardy W
(Dr.dr SpS, DFM)
anwar wardy w
WHO Histologic
Classification of CNS tumors:
Neuroepithelial
Tumors
Astrocytic tumors
Oligodemdroglial
tumors
Ependymal tumors
Mixed gliomas
anwar wardy w
Embryonal tumors
Tumors of cranial/
spinal nerves
Mesenchymal tumors,
benign
Mesenchymal tumors,
malignant
Uncertain histogenesis
Hemopoietic neoplasms
Cysts/tumorlike lesions
Sellar tumors
Roles of Radiotherapy in
Brain Tumor
Incomplete surgery
Deep seated tumor: midbrain,
pons
Radiosensitive tumor:
medulloblastoma
Pituitary adenoma
Palliation: metastatic lesions
anwar wardy w
Acute reaction
Brian edema
Necrotizing leukoencephalopathy
Somnolence Syndrome
anwar wardy w
TUMOR OTAK
Definisi:
Sebarang sel atau pertumbuhan yang
abnormal dalam intrakranial (primer)
yang mungkin benigna atau maligna
ataupun sekunder metastase.
JENIS-JENIS TUMOR
Tumor primer
Pertumbuhan yang berasal dari otak dan tidak
merebak ke luar otak. Contohnya ialah Tumor
Glioma dan Tumor 'Non Glial'.
- Tumor Glioma
(tumor yang terjadi pada sel glial dalam sistem
saraf), astrocytes (astrocytomas), ependymal cells
(ependymoma)
anwar wardy wfk.UMJ
dept.neurology
2013
Tumor
type
Performance status
Extent of surgery
anwar wardy w
INTRAKRANIUM METASTATIC
DISEASE (IMD)
Definisi:
Sejenis
tumor
intrakranial
sekunder yang berasal dari luar
otak dan metastasis kepada otak
MANIFESTASI KLINIKAL
Tak semua ada pada sign/syndrom,..
Sakit kepala (60%)
Sakit kepala yang lama (khronis)
Kesakitan di bahagian supra orbital
Penglihatan kabur
Diplopia (penglihatan berganda)
Nausea & Vomiting (early morning)
Non responsis terhadap obat nyeri
anwar wardy wfk.UMJ
dept.neurology
2013
Roles of Whole
Cerebrospinal Axis Irradiatio
n:
Medulloblastoma
Ependymoma: esp. poorly
differentiated type
Malignant glioma of posterior fossa
Pinealoma
Choroid plexus papilloma
Reticulum cell sarcoma of the brian
anwar wardy w
SUPPORTINGINVESTIGASI
1.
2.
3.
4.
5.
6.
MRI scan
2.
3.
4.
Tumor
sakit kepala yang terus2an selama
berminggu minggu.
Meningitis
Sakit kepala bersama dengan tanda
iritasi meningeal.
Abses otak bengkak disebabkan
postinfeksi (Pseudo-tumor)
Migran
Sakit kepala yang tidak berhenti
dengan muntah projectil
PRINCIPLES OF
TREATMENT:
Surgery:
initial treatment
Radiotherapy
Chemotherapy
-obat sitotoksik
-Hormonal manipulation
-Steroid
Combine treatment
anwar wardy w
Pembedahan
neuroimaging
molecular
clincal\pathology
Integrated
Analysis
anwar wardy w
Oligodendroglioma
Vessel
Morphology:
anwar wardy w
Astrocytoma
Necrosis:
MORPHOMETRIC ANALYSIS
anwar wardy w
Morphological Correlates of
Genomic Analysis
Nuclear
Characterization
Classical
Tissue
Classification
Nuclear Priors
Nuclear
Classification
(Neoplastic Oligodendroglia,
Neoplastic Astrocytes,
dept.neurology...)
fk.UMJ 2013
Reactive Endothelial,
Class
anwar wardy w
Summary
Statistics
Proneural
Mesenchymal
Neural
Dataset
anwar wardy w
Region type
Normal
45
Astrocytoma
20
Oligodendroglio
ma
54
Oligoastrocyto
ma
29
Glioblastoma
18
Total
166
anwar wardy w
Komplikasi
SOL: Oedem dan Metastasis
Defisit Neurologis.
Prognosis
Tidak baik
Anjuran / Nasihat;
1.
2.
3.
Berfikiran positif
Obat2an rutine sesuai arahan dr
Datang/kontrol teratur.
Astrocytoma
Grade
sites)
Grade
Grade
I (cerebellar)
90-100
- Grade I (all
50-60
II
16-46- Grade III 10-30
IV
0-10
Medulloblastoma 40-50
Ependymoma
40-55
Oligodendroglioma
50-80
Brain stem 20-30
3rd ventricle+midbrain 25-35
Pinealoma
50-90
anwar wardy w
KESIMPULAN:
TUMOR OTAK DEWASA,
RESIKO, DIAGNOSIS, DAN
Massa atau
pertumbuhan sel abnormal
PENGOBATAN
References
Malik, J., Belongie, S., Shi, J., and Leung, T. 1999.
Textons, contours and regions: Cue integration in
image segmentation. In Proceedings IEEE 7th
International Conference on Computer Vision, Corfu,
Greece, pp. 918925.
O. Tuzel, L. Yang, P. Meer, and D. J. Foran.
Classification of hematologic malignancies using
texton signatures. Pattern Anal. Appl., 10(4):277290,2007.
M. Varma and A. Zisserman. Texture classification:
Are filter banks necessary? In Proceedings of the
IEEE Conference on Computer Vision and Pattern
Recognition, pages 691-698, 2003.
anwar wardy w
Wassalam,
Terima kasih
Jakarta, Januari 2013
Anwar Wardy W
anwar wardy w