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(Psoriasis Vulgaris)(MMP-2)
(TIMP-2)(MVD)
(Relationship between the Expression of MMP-2/ TIMP-2 and Microvessel
Density in Psoriasis Vulgaris)

2010-03-30

Psoriasis VulgarisMMP-2
TIMP-2MVD

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1710
MMP-2TIMP-2SP
(MVD)CD34
P<0.01

r = 0.625, P<0.01
r = -0.424, P<0.01

Abstract
Objective: To study the relationship between the expression of matrix
metalloproteinase-2 (MMP-2) tissue inhibitors of metalloproteinase-2 (TIMP-2)
and microvessel densityMVDin patients with psoriasis vulgaris.

Methods: The biopsies were taken from psoriatic lesions in 17 patients with active
psoriasis vulgaris and the skin of 10 normal controls. The expression of MMP-2
and TIMP-2 were detected by the SP immunohistochemical method. MVD was
detected by immunohistochemical method with monoclonal antibody specific for
the endothelial marker CD34.
Results: MVD in the lesions of psoriasis vulgaris was higher than that in normal
control (P<0.01). MMP-2TIMP-2 were expressed moderate to intense staining
in the psoriatic lesions but very weak to absent in the normal skin. The
expression level of MMP-2 was positive correlation with MVD(r=0.625
P<0.01),and TIMP-2 was negative associated with MVD in active psoriasis
vulgaris(r=-0.424P<0.01).
Conclusion: The overexpression of MMP-2 could be responsible for cell-cell and

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cell-matrix changes noted in psoriatic epidermis. Downregulation of TIMP-2 that

may serve as an aetiological factor in the development of psoriasis. The abnormal
expression of MMP-2 TIMP-2 protein are closely correlated with the increase of
MVD in psoriatic lesions. These findings indicate that there is a close correlation
between the state of the superficial vasculature and the clinical status of
psoriasis.It was concluded that MMP-2TIMP-2 might play important roles in the
occurrence and progression of angiogenesis in psoriasis. Further mechanistic
investigations are required with the potential that MMP-2TIMP-2 protein may
be help to explain the pathogenesis of microvascular abnormalities in psoriatic
skin.The expanded superficial microvascular bed in psoriatic skin is a necessary
component for maintaining clinical lesions and these blood vessels are thus a
legitimate target for treatment.

: 1326
: (02)2507-0603 : (02)2503-2877
E-mail:tccma100@ms81.hinet.net

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