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CAV-1MMP-2(The Expression of
CAV-1 and MMP-2 in Patients with Psoriasis Vulgaris)

2012-06-05

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CAV-1MMP-2

SP65CAV-1MMP-2
15MMP-2
(P<0.01); CAV-1(P<0.05). CAV-1MMP-2
(r=-0.425P<0.01)

CAV-1/MMP-2MMP-2
Abstract

Objective: To explore the expression of caveolin-1 (CAV-1)and matrix

metalloproteinase -2(MMP-2)in patients with psoriasis vulgaris and its clinical
significance.

MethodsThe biopsies were taken from skin lesions in 65 patients with

psoriasis vulgaris and the skin of l5 normal controls. The expression of CAV-1 and
MMP-2 were detected by the SP immunohistochemical method.

Results: The expression level of MMP-2 in psoriasis vulgaris were significantly

higher than that in the normal controls(P<0.01); the expression of CAV-1 in psoriasis
vulgaris were lower that in the controls(P<0.05).CAV-1 was negative associated with
MMP-2 in psoriasis vulgaris (r=-0.425P<0.01). Conclusion: It was concluded that
CAV-1MMP-2 might play important roles in the occurrence and progression of
psoriasis, which suggested that CAV-1 might inhibit secretion of MMP-2.
Downregulation of CAV-1 that may serve as an aetiological factor in the
development of psoriasis.The overexpression of MMP-2 could be responsible for
cell-cell and cell-matrix changes noted in psoriatic epidermis.Further mechanistic
investigations are required with the potential that CAV-1/MMP-2 protein may be a
novel target for therapy of psoriasis.

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