Oxidoreductases-theseenzymescatalyseoxidoreduction

Transferases-theseenzymescatalysethetransferofa
chemicalgroupfromdonortoacceptor.
Hydrolases-theseenzymescatalysethehydrolysisof
variousbonds.
Lyases-theseenzymescleavingbondsbyothermeans
thanbyhydrolysisoroxidation.
Isomerases-theseenzymescatalysechangeswithinone
molecule.
Ligases-theseenzymescatalysethejoiningoftwo
moleculeswithconcomitanthydrolysisofthediphosphate
bondintriphosphates.

Vitamin

Coenzyme

Function

niacin

nicotinamideadenine
dinucleotide(NAD+)

oxidationor
hydrogen
transfer

riboflavin

flavinadeninedinucleotide
(FAD)

oxidationor
hydrogen
transfer

pantothenicacid

coenzymeA(CoA)

Acetylgroup
carrier

vitaminB-12

thiamin(B-1)

coenzymeB-12

thiaminpyrophosphate(TPP)

Methylgroup
transfer

Aldehydegroup
transfer

niacin
nicotinamideadeninedinucleotide(NAD+)
oxidationorhydrogentransfer
riboflavin
flavinadeninedinucleotide(FAD)
oxidationorhydrogentransfer
pantothenicacid
coenzymeA(CoA)
Acetylgroupcarrier
vitaminB-12coenzymeB-12
Methylgrouptransfer
thiamin(B-1)
thiaminpyrophosphate(TPP)
Aldehydegrouptransfer

CoEnzyme

Thereactionistoconvertthealcohol,ethanol,intoethanal,an
aldehyde.
Reaction:CH3CH2OH+NAD+--->CH3CH=O+NADH+H+

,app

2H
2H22O
O2+ O2

ECimportant Reaction
Some
therapeutic enzyme
Use
number

Enzyme

Asparaginase 3.5.1.1

L-Asparagine H2O L-aspartate + NH3

Leukaemia

Collagenase

3.4.24.3

Collagen hydrolysis

Skin ulcers

Glutaminase

3.5.1.2

L-Glutamine H2O L-glutamate + NH3

Leukaemia

Hyaluronate hydrolysis

Heart attack

Hyaluronidas
3.2.1.35
ea
Lysozyme
Rhodanaseb

3.2.1.17
2.8.1.1

Ribonuclease 3.1.26.4
b-Lactamase

3.5.2.6

Streptokinase
3.4.22.10
c

Bacterial cell

wall hydrolysis

Antibiotic

S2O32- + CN- SO32- + SCN-

Cyanide
poisoning

RNA hydrolysis

Antiviral

Penicillin penicilloate

Penicillin
allergy

Plasminogen plasmin

Blood clots

Trypsin

3.4.21.4

Protein hydrolysis

Inflammation

Uricased

1.7.3.3

Urate + O2 allantoin

Gout

3.4.21.31

Plasminogen plasmin

Blood clots

Urokinasee