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  • 1-9 Hyperparathyroidism - Hesham Hamouda

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    Primary hyperparathyroidism is caused by overproduction of parathyroid hormone (PTH) which increases serum calcium levels. PTH is normally secreted in response to low calcium levels and acts to raise calcium through bone resorption and kidney reabsorption. The most common causes are a single adenoma (85%) or multiple adenomas (5%), while hyperplasia accounts for 10% of cases. Primary hyperparathyroidism increases in incidence and prevalence with age and is more common in postmenopausal women. Chronic high PTH leads to increased bone turnover and resorption.

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    1-9 Hyperparathyroidism- hesham hamouda

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    Primary hyperparathyroidism is caused by overproduction of parathyroid hormone (PTH) which increases serum calcium levels. PTH is normally secreted in response to low calcium levels and acts to raise calcium through bone resorption and kidney reabsorption. The most common causes are a single adenoma (85%) or multiple adenomas (5%), while hyperplasia accounts for 10% of cases. Primary hyperparathyroidism increases in incidence and prevalence with age and is more common in postmenopausal women. Chronic high PTH leads to increased bone turnover and resorption.

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    67 views1 page

    1-9 Hyperparathyroidism - Hesham Hamouda

    Uploaded by

    tarikeops
    Primary hyperparathyroidism is caused by overproduction of parathyroid hormone (PTH) which increases serum calcium levels. PTH is normally secreted in response to low calcium levels and acts to raise calcium through bone resorption and kidney reabsorption. The most common causes are a single adenoma (85%) or multiple adenomas (5%), while hyperplasia accounts for 10% of cases. Primary hyperparathyroidism increases in incidence and prevalence with age and is more common in postmenopausal women. Chronic high PTH leads to increased bone turnover and resorption.

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    of 1

    Primary Hyperparathyroidism

    Hisham Hamoud
    Rheumatology Department,Al-Azhar university

    Low circulating serum calcium concentrations stimulate the parathyroid


    glands to secrete PTH, which mobilizes calcium from bones by osteoclastic
    stimulation. PTH also stimulates the kidneys to reabsorb calcium and to
    convert 25-hydroxyvitamin D3 (produced in the liver) to the active form, 1,25-
    D3, which stimulates GI calcium absorption. High serum calcium
    concentrations have a negative feedback effect on PTH secretion.
    Etiology:

    1. Single Adenoma 85%

    2. Multiple Adenomas 5%

    3. Hyperplasia 10%

    4. Carcinoma < 1%

    • Incidence 42/100,000

    • Prevalence 1/1000

    • Female:male = 2-3:1

    • Incidence increases with age

    • Postmenopausal women:

    1. Incidence 5x general population

    2. Prevalence 4/1000

    • Bone effects (immediate control of blood Ca)

    • Causes calcium bone release within minutes

    • Chronic elevation increases bone remodeling and increased


    osteoclast-mediated bone resorption

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