Scribd Logo
Upload

Welcome to Scribd!

  • Antivirusni Lekovi

    Uploaded by

    Milos Stanojevic
    188 views23 pages
    This document discusses various antiviral drugs used to treat HIV and other viral infections. It describes several classes of antiretroviral drugs used to treat HIV, including nucleoside/nucleotide reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, and protease inhibitors. It also discusses antiviral drugs to treat herpes viruses, influenza viruses, cytomegalovirus, and others, explaining their mechanisms of action and common side effects.

    Original Description:

    Mikrobiologija Antivirusni lekovi

    Original Title

    ANTIVIRUSNI LEKOVI

    Copyright

    © © All Rights Reserved

    Available Formats

    PPT, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    This document discusses various antiviral drugs used to treat HIV and other viral infections. It describes several classes of antiretroviral drugs used to treat HIV, including nucleoside/nucleotide reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, and protease inhibitors. It also discusses antiviral drugs to treat herpes viruses, influenza viruses, cytomegalovirus, and others, explaining their mechanisms of action and common side effects.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as ppt, pdf, or txt
    188 views23 pages

    Antivirusni Lekovi

    Uploaded by

    Milos Stanojevic
    This document discusses various antiviral drugs used to treat HIV and other viral infections. It describes several classes of antiretroviral drugs used to treat HIV, including nucleoside/nucleotide reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, and protease inhibitors. It also discusses antiviral drugs to treat herpes viruses, influenza viruses, cytomegalovirus, and others, explaining their mechanisms of action and common side effects.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as ppt, pdf, or txt
    of 23

    ANTIVIRUSNI LEKOVI

    Anti HIV lekovi


    inhibitori reverzne transkriptaze
    (nukleozidni inhibitori reverzne
    transkriptaze i nenukleozidni inhibitori
    reverzne transkriptaze)
    inhibitori proteaza
    visokoaktivna antiretrovirusna terapija
    (HAART, highly active antiretroviral
    therapy)

    Nukleozidni inhibitori reverzne


    transkriptaze

    zidovudin
    abakavir
    lamivudin
    didanozin
    zalcitabin
    stavudin

    pod dejstvom enzima elije domaina


    ovi lekovi se fosforiliu trifosfatni oblik
    kompetencija sa intracelularnim
    trifosfatnim oblikom koji je supstrat za
    formiranje reverzne transkriptaze

    ZIDOVUDIN

    analog timidina
    per os, i.v.
    anemija i neutropenija
    rezistencija

    DIDANOZIN (analog deoksiadenozina)


    dozno-zavisni bol i senzorni poremeaji
    ZALCITABIN
    homolg citozina
    LAMIVUDIN
    analog citozina
    STAVUDIN
    analog timidina
    ABAKAVIR
    analog gvanozina

    NENUKLEOZIDNI INHIBITORI
    REVERZNE TRANSKRIPTAZE
    vezuju se za reverznu transkriptazu u
    blizini katalitikog mesta i dovode do
    njene denaturacije

    EFAVIRENZ
    jednom dnevno se primenjuje
    NEVIRAPIN
    osip po koi

    INHIBITORI PROTEAZA

    sakvinavir
    nelfinavir
    indinavir
    ritonavir
    amprenavir
    per os
    inhibiraju citohrom P450 enzimski sistem
    buffalo torzo

    Ostali antivirusni lekovi uglavnom


    deluju kao inhibitori DNK polimeraze ili
    spreavanjem vezivanja virusa za eliju
    ACIKLOVIR
    derivat gvanozina
    pod dejstvom timidin kinaze se
    konvertuje u monofosfat, aktivan
    iskljuivo u inficiranim elijama

    ACIKLOVIR
    Kinaze iz elija domaina kovertuju
    monofosfat u trifopsfat
    aciklovir-trifosfat inhibira virusnu DNK
    polimerazu
    inaktivira se u elijama domaina
    dejstvom fosfataza
    zaustavlja rast virusnog DNK lanca

    Lekovi slini acikloviru: valaciklovir i


    famciklovir
    Valaciklovir je prekursor aciklovira
    Famciklovir se metabolie u svoju
    aktivnu formu penciklovir

    GANCIKLOVIR
    aciklini analog gvanozina
    aktivna forma je trifosfat koji selektivno
    inhibira virusnu DNK polimerazu jer
    stupa u kompetenciju sa gvanozin
    trifosfatom za inkorporaciju u rastui
    virusni DNK lanac
    suprimira virusnu DNK replikaciju
    intravenska primena

    TRIBAVIRIN (RIBAVIRIN)
    sintetski nukleozid slian gvanozinu
    deluje na sintezu virusne iRNK
    u obluku aerosola koristi se u terapiji
    influence

    FOSKARNET
    (FOSFONOFORMAT)
    sintetski nenukleozidni analog
    pirofosfata
    vezuje se za DNK polimerazu i
    spreava odvajanje pirofosfata iz
    nukleozidnih trifosfata i tako blokira
    formiranje DNK lanca
    i.v., lek drugog izbora u terapiji
    citomegalovirusne infekcije
    moe biti nefrotoksian

    Foskarnet sodium

    AMANTADIN
    derivat adamantana u obliku
    hidrohlorida
    deluje na rane faze replikacije i
    penetracije
    deluje specifino na na influenca A
    virus
    deluje na M2 protein koji se pojavljuje
    na povrini inficirane elije
    per os

    RIMANTADIN
    deluje samo na virus influence A
    manje efikasan od amatadina

    VIDARABIN
    analog purinskih nukleozida
    antivirusno dejstvo prema virusima
    herpes grupe
    inhibira sintezu virusne DNK
    deluje u fosforilisanom obliku

    ZANAMIVIR

    inhibitor dejstva neuroaminidaza


    aktivan protiv virusa influence A i B
    za inhalaciju
    OSELTAMIVIR (Tamiflu)

    You might also like