17

27

37

Tabel 1. Poison syndromes

47

the primary enzyme responsible for biosynthesis

certain other autocoids.
this disruption product the side effects reported with therapeutic use, such as
gastrointestinal irritation, reduced renal blood flow and platelet dysfunction.
NSAID analog have been developed that are move specified for the inducible
form of (COX 2 isoform) vs the constitutive form, the COX 1 isoform.
These drugs attempt to minimize or
reduce the occurrence of therapy-associated adverse effects.
Overdose of the more selective COX-2 inhibitors (celecoxib
[Celebrex]) is treated no differently than for nonspecific COX
inhibitors (ibuprofen) because at higher doses, COX-2 selective agent lose their
COX inhibitory selectivity. ibuprofen, the primary NSAID used in pediatrics, is well
tolerated, even after overdose.

57

1. Darmansjah. Toksikologi: farmakologi dan terapi edisi 5. Balai penerbit

FKUI. Jakarta. 2011. P 820
2. Alwi, Enny. Tata laksana keracunan: buku ajar gawat darurat. IDAI. Jakarta.
2013. p 268
3. Olson, Kent., McGuigan, M. toksikologi dan kecelakaan: buku ajar pediatrik
Rudolph. EGC. Jakarta. 2014. p 896
4. Regor, tamara. Evaluation and management of common childhood poisonings.
American Academy of Family Physicians journal. Vol 79 (5). 2009. Diakses
dari

http://www.aafp.org/afp/2009/0301/p397.html

pada

tanggal

18/08/2015
5. Leeder, Steven., Koren, Gideon. Pediatric drug therapy: Nelson Ilmu Kesehatan Anak

Edisi 18 Volume 1, Jakarta: EGC, 2000.

6. Farrel, susan. Acetaminophen toxicity. Emedicine. Medscape. 2014 diakses
dari http://emedicine.medscape.com/article/820200-overview pada
tanggal 19/08/2015
7. Waseem, Muhammad. Salicylate toxicity. . Emedicine. Medscape. 2014
diakses dari http://emedicine.medscape.com/article/1009987-overview
pada tanggal 19/08/2015
8. Lusiana, darsono. Diagnosis dan terapi salisilat dan parasetamol.
Jurnal farmakologi. Fakultas Kedokteran, Universitas Kristen
Maranatha. Bandung. 2011
9. Lung, Derrick. Tricyclic antidepressant toxicity in pediatrics.

Emedicine. Medscape. 2015 diakses dari

http://emedicine.medscape.com/article/1010089-overview Pada
tanggal 19/08/2015
10.
11. Sahin, sabiha., Carman, kursat. Acute poisoning in children: data of pediatric

emergency. US national library of medicine national institute of health journal. 2011.

Diakses dari http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446134/ pada tanggal
20/08/2015

67