Introduction to

genetics
January 7, 2015
Bio202L

Responses from your class to

pre-class quiz
Areas that were confusing
Darwin vs. Lamarck/ Mendel
What are gemmules?

Process of DNA -> proteins (Bio201L)

Intergenic regions vs. introns

Areas that were interesting

Blending inheritance
Personal genotype services / 23andMe
controversy

Introns vs. Intergenic

regions
Chek2

Nf2

Sox10

AUG GAC GCG GAU UAU GGA GGA AGA UUA AGA
AAC GGA gua agu uua ugg aac ccc cau ag AGG
GCA
GGG UAA
DNA template that made RNA: 71 bp (has T not U)
Initial RNA (before mRNA): 71 bp
mRNA (intron spliced): 48 bp
UAA is stop codon not coding an amino acid

How many amino acids would be in the

protein produced by this RNA?
(Assume it is in frame)

AUG CCC GCG GAU GGA GGA AGA UUA AGA

AAC gua agu uua ugg aac ccc cau ag GGA
UAA

How many amino acids would be in the

protein produced by this RNA?
(Assume it is in frame)

AUG CCC GCG GAU GGA GGA AGA UUA AGA

AAC gua agu uua ugg aac ccc cau ag GGA UAA
Multiple choice:
10
11
12
33
36

Code in cells...
So, genetics is this code thats
found inside every single cell of your
body
Not exactly true...
Mature red blood cells dont have nuclei
or nuclear DNA

Code in cells...
So, genetics is this code thats
found inside every single cell of your
body
Not exactly true...
Mature red blood cells dont have nuclei
or nuclear DNA
Code not exactly the same in every
cell!

Mutations happen during

development
Start as single cell (fertilized egg)
Divide multiple times
Some errors happen with
replication
Especially true with cancer cells
Sometimes hundreds of
nucleotide differences!
Extensive tumor diversity
within individual person
Subset of cells may be less
responsive to chemotherapy
Jarkko Samuli Vanhalakka
huup://www.elfwood.com/~jakke/I-wanna-be-a-

Lots for next week

Videos for Friday (videos 1-4 through 1-6)
Videos for Monday (videos 2-1 through 23b)
Material for Monday is one that people
find challenging
Watch videos early!
Try problems early!
Optional: apps to help

Problem set due Tuesday noon!

In-class quiz Wednesday!

ASSESSMENT QUIZ
Your performance on this quiz
will NOT affect your grade in
this class.
It is to give us information on
the range of preparation in this
class and to help with group
assignments.

QUESTIONS?
COMMENTS?
Come up front and chat with TAs and
me!