Whitfields Ointment:

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Whitfields Ointment
Whitfields ointment (ointment base) benzoic acid
6 salicylic acid 3 petrolatum
benzoic acid salicylic acid Whitfields ointment
ant-inflammation, keratolytic, anti-septic antiinfective corticosteroids, propylene glycol sulfur
Whitfields ointment
benzoic acid salicylic acid ointment base
(high lipophilicity) (hydrophobic) (non
washable by water) (greasy)
(occlusive) emollient
(water-soluble
irritant)

Benzoic acid fungistatic agent

benzoic acid antiseptic
salicylic acid anti-fungal
Salicylic acid
keratolytic bacteriostatic fungicidal
keratolytic salicylic acid

salicylic acid

salicylic acid

sulfur Whitfields ointment

keratolytic acidic media alkali media keratolytic
sulfur pentothionic
acid antiseptic antiseptic greasy base
1

 Whitfields ointment 10-20 keratolytic

1-2 5 3 3
keratolytic 7 keratolytic antiseptic
Whitfileds ointment sulfur (antipruritic)

Whitfields Ointment
Whitfields ointment
(Dermatophytes)
(Tinea versicolor) Candida spps. (Hall-Smith, 1974)
Whitfields ointment
azole antifungals
clotrimazole (Clayton, 1979) azole antifungals
Whitfields ointment non-inferior study (Clayton, 1974)
cure rate failure
rate (Comaish, 1974; Clayton, 1979) azole antifungals

Whitfields ointment
Whitfields ointment Whitfields ointment



Clayton YM Connor BL double-blind 4
Whitfields ointment clotrimazole cream
Candida spp.
4 88
(Clayton, 1973)
Gooskens V double-blind
Whitfields ointment clotrimazole cream
Dermatophyte 153 25
HIV-1 Whitfields ointment clotrimazole
cream 6
75 Whitfield's ointment 78 clotrimazole
cream (cure rate)
80-90
2

 6 (treatment
failure) 6
HIV-1 1 Whitfields
ointment clotrimazole cream
HIV-1 Whitfields
ointment clotrimazole cream
(Gooskens V, 1994)
griseofulvin
Wright S
randomized controlled trial
6

Whitfields ointment miconazole cream
(Wright S, 1986)
Whitfields ointment azole
antigungals
superficial fungal infection Whitfields
ointment (standard treatment) clotrimazole cream (
, 2548)
Whitfields ointment
Corynebacterium minutissimum
erythrasma Dermatophytes
Dermatophytes Candida spp.
erythrasma
erythromycin clindamycin solution, sodium
fusidate ointment, chloramphenicol Whitfields ointment
erythrasma
erythrasma Whitfields ointment
erythromycin Whitfields ointment sodium fusidate
ointment Whitfields ointment erythrasma
(Holdiness M, 2002, Clayton Y, 1973)
Whitfields Ointment



2
:




:

triamcinolone
cream betamethasone cream


Whitfields ointment
3
Whitfields ointment



Whitfields ointment
(Holdiness MR, 2002) sulfur antiseptic

Whitfields ointment
Vaseline petrolatum jelly
ointment base whitfields ointment

4

 Whitfields ointment
clotrimazole cream Whitfields ointment


Whitfields ointment

Whitfields Ointment
Whitfields ointment
Whitfields ointment 2-3
2-4
Whitfields ointment



calamine lotion zinc oxide
Whitfields ointment

Hay RJ. Fungal infections. Clinics in Dermatology 2006; 24(3): 201-12.

Hay RJ. Treatment of superficial fungal infections. Clin Exp Dermatol 1986; 6: 509-13.
Weinstein A, Berman B. Topical Treatment of Common Superficial Tinea Infections. Am Fam
Physician 2002; 65(10): 2095-2103.
Williams H, Bigby M, Diepgen T, Herxheimer A, Naldi L, Rzany B. Evidence-based dermatology.
2nd ed. Massachusetts: Blackwell publishing; 2008.
Zaidi Z, Lanigan SW. Dermatology in clinical practice. New York: Springer-Verlag; 2010.

Clayton YM, Connor BL. Clinical trial of clotrimazole in the treatment of superficial fungal
infections. Postgrad Med J 1974; 50(Suppl 1): 66-9.

Clayton YM, Connor BL. Comparison of clotrimazole cream, Whitfield's ointment and Nystatin
ointment for the topical treatment of ringworm infections, pityriasis versicolor,
erythrasma and candidiasis. Br J Dermatol 1973; 89(3): 297-303.
Clayton YM. Dermatophyte infections. Postgrad Med J 1979; 55(647): 605-7.
Comaish JS. Double-blind comparison of clotrimazole with Whitfield's and nystatin ointments.
Postgrad Med J 1974; 50(Suppl 1): 73-5.
Gooskens V, Pnnighaus JM, Clayton Y, et al. Treatment of superficial mycoses in the tropics:
Whitfield's ointment versus clotrimazole. Int J Dermatol 1994; 33(10): 738-42.
Hall-Smith P. Dermatomycoses: a brief history of therapy and initial results with clotrimazole.
Postgrad Med J 1974; 50(Suppl 1): 70-2.
Holdiness MR. Management of cutaneous erythrasma. Drugs 2002; 62(8): 1131-41.
Wright S, Robertson VJ. An institutional survey of tinea capitis in Harare, Zimbabwe and a trial
of miconazole cream versus Whitfields ointment in its treatment. Clin Exp Dermatol
1986; 11: 371-7.
, , . Clinical practice guideline in superficial
fungal infection. Available at:
http://www.dst.or.th/files_news/Superficial_Fungus_Infection1.pdf. Accessed
September 25, 2011.