A drenal Steroid Synthesis

Adrenal Steroid Synthesis

R: Chapter 24
Phys: Chapter 77
H: Chapter 342
Adrenal anatomy (FA12 p314) (FA13 p286) (R p1148) (Phys p921)
Fetal adrenal gland (FA12 p314) (FA13 p286)
Steroid synthesis (FA12 p318) (FA13 p291) (SU13 p210) (Phys p923) (H p2940)
Congenital adrenal hyperplasia (FA12 p318) (FA13 p291) (SU13 p209-210) (R p1152) (H p2959)

3 Question Warm-Up
1. What is the precursor molecule of ACTH synthesis?

2. What is required for a molecule to enter into the nucleus through a nuclear pore?

3. What are the various clinical applications of atropine? (FA12 p266) (FA13 p234) (SU13 p340)

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A drenal Steroid Synthesis

4. Complete the steroid synthesis pathway:

N.

B.

O.

C.

P.

D.

Q.

E.

R.

F.

S.

G.

T.

H.

U.

I.

V.

J.

W.

K.

X.

L.

Y.

M.

Z.

5. What features characterize a deficiency in 3-hydroxysteroid dehydrogenase?

Inability to produce

6. What features characterize a deficiency in 17-hydroxylase?

Inability to produce sex hormones and cortisol

Increased production of mineralocorticoids (i.e. aldosterone) sodium and fluid retention

7. What features characterize a deficiency in 21-hydroxylase?

Inability to produce cortisol
Inability to produce mineralocorticoids
Increased production of sex hormones

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ENDOCRINE

A.

A drenal Steroid Synthesis

8. What features characterize a deficiency in 11-hydroxylase?

Inability to produce
Increased production of deoxycorticosterone (a weak mineralocorticoid)
Increased production of sex hormones

End of Session Quiz

9. What are the symptoms of 21-hydroxylase deficiency? (FA12 p318) (FA13 p291)
(SU13 p210)

10. What are the symptoms of 11-hydroxylase deficiency? (FA12 p318) (FA13 p291)
(SU13 p210)

11. What food substance is an essential starting point in the synthesis of adrenal steroids?
(FA12 p318) (FA13 p291) (SU13 p210)

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