Study population ()

The Malmo preventive project (MPP) cohort

Malmo 1974 1974 1992 22,444

10,902 ( 70%) intervention



spirometry
intervention ( , ) 25%


1974-1982 1977-1992
fasting plasma

insulin (FPI)

1975-1979

MPP cohort
FPI (n=7298)
11 case AF 213 case diabetes at baseline

1
7
SBP
6052 1014
FBG

Data collection (
)
(m) Fixed stadiometer (kg) Balance
beam scale Systolic blood pressure (SBP) (mmHg) 2 10
Sphygmomanometer with a modifiable cuff

Malmo FBG glucose-oxidase method

(1974-1977) hexokinase-oxidase method (1977-1992)

FPI nonspecific radioimmunoassay (RIA) method
-1
-1
-1
detection limit 3 mIU L (nmol L = mIU L x 7.175/1000)

Molmo
RIA method

oral glucose tolerance (OGTT; 30g glucose in/m2 body
surface at the beiginning of the study and a fixed dose of 75g in the later part of the

study)

5476(90%)
OGTT 120 Sedentary life-style
896(88%)

?
2 Malmo modification of the
Michigan Alcohol Screening Test (MM-MAST)
Statistics Sweden socioeconomic index (SEI) group 11-36

National registries ( )
Swedish Hospital Discharge Register
The Swedish National Board of Health and Welfare
AF atrial flutter
AF
(diagnosis codes 427D for the 9th revision of International Classification of Diseases,
ICD-9, and I48 for the 10th revision, ICD-10)
30 2009 AF atrial flutter


Helsinki
Lund (number 85/2004)

Statistics ()

STATA Windows version 12.1

cohort power function EPISHEET by Rothman (available at
http://www.epidemiolog.net webcite)
(FPI FBG) log
transformed FPI

(per
log
unit)
quartiles Cox

regression competing risks regression

BMI
FBG SBP baseline 2
1 2 SBP
total cholesterol, triglycerides, sedentary
lifestyle, alcohol use low socioeconomic status

, FBG, BMI, SBP, smoking status, ,
interaction parameter


interaction parameter

borderline
interaction parameter

interaction parameter

Cox regression Nelson-Aalen plots. A twosided p-value of <0.05