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Be418 Major 08
Be418 Major 08
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~ Diagrammatically show the protein structure hierarchy. What different public domain databases are
available for protein information? Jib t-~ f\- ~ oJo..G c7J1l l fJ~ s7 ( Q)
~ExPlain various indicators that help to give the level of confidence while evaluating a relationship
between a query sequence and other sequences existing in any database. ~
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Write briefly on the concepts, namel~ Mutation vs Substitutions (0.5) ~kes-Cantor
Molecular Clocks & Relative rate tests m.
Model M)
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JA. Dmw the phylogenetic tree (use std symbols) that corresponds to the one described in the standard
Newick Format as «(A, B), C), (D, E), F). Number the internal nodes using Roman numerals I, II, iiI, ...
How many internal nodes are created? (1+0.5+~ m
~raw all the possible unrooted trees for the species A, B, C, & D and only 8 out of all the possible
rooted trees of these four species. (1+6) (J)
~se UPGMA to reconstruct a phylogenetic tree using the following distance matrix. Using this example
expl '-'-.
Species A B C D
B 6 - - -
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C
D
12
18
10
18
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20
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E 24 22 26 18
~ Briefly describe Parsimony Method of phylogeny with the help of an example. The concept of
informativesiteanduninformativesite shouldalsobe explained. (2.5) ...
J. W"" ,hort oot" o~"oo" ,xon, andal;,;o." 'PI;Ci~'ochore' ane/J g,oe d,n,ity. (4.5)
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