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Evolution of Anti-Filarial Therapeutics: An Overview
Evolution of Anti-Filarial Therapeutics: An Overview
Received
ABSTRACT
07 April 2015
population - almost equal to that affected by malaria involving approximately 73 countries, yet it has been considered a less significant disease. This probably is the reason for its unfortunate tag of neglected tropical disease.
KEY WORDS:
Lymphatic filariasis
Therapeutics
New targets
Novel rationale
At present, there are over 120 million infected individuals, and above 40 million of them have been disfigured
and severely debilitated by the disease. Therefore, WHO
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itats in the host [6]. It has also been reported that the drug
tin only against Mf, and not adult worms is yet to be elu-
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face
protein
(WSP)
as
determined
by
immuno-
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diseases.
cine and are still in use today. Herbal medicines are being
this view has also been recorded by our earlier work [30].
assault by the cells recruited to elicit inflammatory response as a key mediator of antimicrobial effect [31].
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Concluding remarks
Conflict of Interest
comes from the fact that polyphenols / flavonoids are derivatives from shikimate pathways which are also respon-
Acknowledgement
All authors would like to thank the DBT, India for funds
References
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3
4
5
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