DRUG STUDY

Generic/ Brand
Name
Ampicillin

Action

Classification

Inhibits the
Anti-infective
bacterial enzyme
transpeptidase
thus preventing
crosslinking cell
wall components

Purulent
meningitis in
neonates and
infants: 75
mg/kg QID.

Misoprostol

Reduces gastric
acid secretion
and increases
gastric mucus
and bicarbonate
production

Adults: 200mcg
QID with food,
with last daily
dose given at
bed time.

Anti-ulcerative;
cytoprotective
agent

Indication

Contraindicatio
n
Hypersensitivity
to penicillins;
infectious
mononucleosis

PProstaglandin
hypersensitivity;
pregnancy

Side Effects

Nursing
Intervention
GI disturbance,
Watch for
laryngeal stridor, bleeding
fever, sore
tendency and
mouth or tongue, hemorrhage.
superinfection
Monitor for
signs and
symptoms of
hypersensitivity
reaction.
Check for signs
and symptoms of
infection at
injection site.
Headache,
Assess GI status.
nausea,
Report
vomiting,
significant
diarrhea,
adverse
abdominal pain, reactions.
miscarriage,
Monitor
menstrual
menstrual
disorders
pattern or post
menstrual
building.
Report
significant
problems.

Oxytocin

Thought to
directly
stimulate
smooth muscle
contractions in
uterus and
cervix

Uterine-active
agent

To induce or
stimulate labor.
Adults: Initially,
1ml ampule in
compatible I.V.
solution infused
at 1 to 2
milliunits/
minute. Increase
rate in
increments of 1
to 2 milliunits/
minute q15 to 30
minutes until
acceptable
contraction
pattern is
established.

-Hypersensitivity
to drug
-Cephalopelvic
disproportion
-Fetal distress
when delivery is
not imminent
-prolonged use in
uterine inertia or
severe toxemia

Nausea,
vomiting,
premature
ventricular
contractions

Methergine

Directly
stimulates
vascular muscle
and contractions
in uterus and
cervix and
decreases
bleeding after
delivery.

Oxytocic

Prevention and
treatment of post
partum
hemorrhage.
Adults: 0.2
mgI.M.; repeat
q2 to 4 hours as
needed to a total
of five doses.

-hypersensitivity
to drugs
-hypertension
-toxemia
-pregnancy

Dizziness,
headache,
hallucination,
hypertension,
hypotension,
palpitations,
tinnitus, nausea,
diarrhea,
hematuria

Monitor
contractions,
fetal and
maternal heart
rate and
maternal blood
pressure and
ECG.
Monitor patient
extremely
closely during
the first and
second stages of
labor because of
risk of cervical
laceration.
Assess fluid
intake and
output.
Monitor patient
for adverse
effects. When
giving I.V.
closely monitor
blood pressure,
pulse, uterine
contractions and
bleeding.