Predisposing Factors:

Risk Factors:
Etiologic
Agents:

HPV infections
Sexual history
Smoking
Weakened immune
system
Multi-parity

Unknown
(Idiopathic)

Modifiable:
Stress
Diet
Non- Modifiable:
Age
Gender
Heredity

Exposure to
carcinogens
Decrease immune
system
Invasion of carcinogens in the cells of
the cervix
Mutation inactivates the tumor
suppressor gene
Cells
proliferate
Mutation inactivates DNA
repair gene
Mutation of proto-oncogene creates
oncogene
Mutation inactivates several more tumor
suppressor genes
Abnormal cell forms clone and proliferate
abnormally
Malignant
neoplasm
Impaired circulation
and oxygenation on
the tissue
Necrosis of the
tissues affected by
CA
Foul smelling
vaginal discharge

Gain access to lymph

and blood vessels

Carry cells to other

areas of the body
(METASTASIS)

Pressure on the tissue

of the cervix
Sensation of
pain
Slight trauma and
pressure causes
bleeding