THE FUNCTION OF

GENITAL ORGAN:
1.REPRODUCTION
2.SEXUAL ACTIVITY

FASE PUBERTAS
PRIA

SEXUAL
DEVELOPMENT
1.CHROMOSOMAL SEX
2.GONADAL SEX
3.GENITAL SEX
4.HORMONAL SEX
5.PSYCHOLOGICAL SEX

THE FUNCTION OF TESTIS

1.SPERMATOGENESIS
SPERMATOSITOGENESIS (PROLIFERASI)
MEIOSIS (SPERMATOSIT I AND II)
SPERMIOGENESIS
SPERMATOZOA)

(SPERMATID

SPERMIATION ( PEMATANGAN)
2.STEROIDOGENESIS (ANDROGEN
PRODUCTION )

SPERM ANALYSIS
CONCENTRATION
=>20 MILLION/ML
MOTILITY

>50%

NORMAL MORPHOLOGY
>30%

DEFINITION
A CHEMICAL WHICH IS PRODUCTED BY CELL OR CELL GROUP
IN BODY SOLUTION AND GIVE PHYSIOLOGIC EFFECT ON CELL
REGULATION

THE FUNCTION
IS A CONTROL SYSTEM OF INTEGRATION

NERVE SYSTEM

ENDOCRINE SYSTEM

ORGAN

THE FUNCTION OF HORMON

N
O
I
T
C
U
D
O
R
P
RE
INTE
RNA
ENV
IRON L
MEN
T

GRO
WTH
DEV
ELO AND
PME
NT

Y
G
R
E
EN

THE ANDROGEN
PRODUCTION
1. LEYDIG CELL (INTERSTIAL
CELLS OF LEYDIG), IN
INTERSTITIAL TISSUE OF
TESTIS
2. SUPRARENALIS GLAND ( THE
UPPER OF KIDNEY).

HORMON
1.ANDROGEN
(TESTOSTERON)
2.ESTROGEN

Hormone
Receptor
Effector
2nd Messengers
Protein Kinases

Cytoplasm

Cytoplasm

P
mRNA
Gene
Nucleus

Receptor

HRE
Gene
Nucleus

mRNA

ANDROGEN
(TESTOSTERON)
DEVELOPMENT AND
MAINTENANCE
REPRODUCTIVE
TISSUE
MALE CHARACTERISTIC
SEXUAL DRIVE

SOME FACTORS
INFLUENCE ANDROGEN
FUNCTION ON CELL TARGET
1.THE CONCENTRATION OF STEROID
2.INTERACTION BETWEEN
RECEPTOR AND PROTEIN
3.THE RECEPTOR ACTION IN
GENOMIC
STATE

BIOSYNTESE OF ANDROGEN IN
TESTIS
BIOSYNTESE IN LEYDIG CELLS
CHOLESTEROL SINTESE FROM
GLUCOSE AND FATTY ACID
MITOCHONDRIA BREAK THE CHAIN
OF
KOLESTEROL TO PRODUCES
PREGNENOLONE
PREGNENOLONE ENTER TO
RETICULUM
ENDOPLASMA. THIS PROCESS IS HELP

BIOSYNTESE ANDROGEN IN SEL LEYDIG

LEYDIG CELLS
ACETATE

BLOOD

CHOLESTEROL

CHOLESTEROL

PREGNENOLONE

17 OH-PREGNENOLONE

ANDROSTENEDIONE

OTHER TISSUE

PROGESTERONE

17 OH-PREGNENOLONE

ANDROSTENEDIONE

TESTOSTERONE

ESTRONE

ANDROSTENEDIONE

ESTRONE

ANDROSTENEDIONE

TESTOSTERONE

TESTOSTERONE

ESTRADIOL

ESTRADIOL

CONCENTRATION OF PLASMA
ANDROGEN AND PRODUCTION
STEROID

[PLASMA]
(NG/DL)

(NG/DAY)
TESTOSTERONE
MALE
700
FEMALE
40
ANDROSTENEDIONE
MALE
100
170
DHT
MALE
FEMLE
20

PRODUCTION

7000
300
2500 FEMALE
3500
30

300
60

TESTOSTERONE TRANSPOR
TESTOSTERON
SECRETION TO
SPERMATC VENA,
IS BOUNDED BY
PROTEIN PLASMA
(HIGH AFINITY:
TEBG =
TESTOSTERONEESTRADIOL
BINDING
GLOBULIN WHICH
PRODUCED IN
LIVER

2% FREE T
30% TEBG
68 % IN
ALBUMIN
AND PLASMA
PROTEIN

TRANSFORMATIO
N 5REDUKTASE

DHT SPECIAL
RECEPTOR
IN SOMEPROSTATE
AREA:

EPITEL
GERMINAL
EPIDIDIMIS
DUCTUS
DEFERENS
VESICA
SEMINALIS

HAIR FOLLICEL
SEBACEA GL

THE PHASES OF
MALE PUBERTY

THE PHASES OF
SEXUAL ACTIVITY
EXCITEMENT
PLATEAU
ORGASMIC
RESOLUTION

GOOD MORNING EVERYBODY

EJACULATION

CYCLE OF
MENSTRUATION

1.PROLIFERATION
2.SECRETION
3.MENSTRUATION

BERAPA
HARGA
TUBUH
ANDA/KG?

Rp.
Rp. 2,3
2,3 MILJARD/KG
MILJARD/KG

DR.
DR. MOROVITZ
MOROVITZ

INCREASE THE PRODUCTION OF

MILK TO IMPROVE PHYSICAL
HEALTH AND FITNESS

TQ AND SEE YOU NEXT TIME

SEE YOU NEXT TIME