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Lecture 4 BB1035 C15
Lecture 4 BB1035 C15
Lecture 4 BB1035 C15
Prokaryotic
Binary Fission
Reproduction
Eukaryotic
Mitosis
Meiosis
Origin
Reproduction
Growth
Regeneration/Repair
Cytokinesis
G2-M
transition
Gap 2
(G2)
G2: cell prepares
for mitosis
G1: chromosomes
unreplicated structures
Mitosis
(M)
Gap 1
(G1)
Interphase
DNA synthesis
(S)
DNA replicates
Restriction
G1-S
Transition
(commitment)
Intro to Biotech
Lecture ?4Eukaryotic:
The Cell
Cycle
How is DNA propagated
G1-S-G2-M
G2-M
transition
Mitosis
(M)
Gap 2
(G2)
Gap 1
(G1)
Interphase
DNA synthesis
(S)
Restriction
G1-S
Transition
Cell cycle
transitions depend on kinases
Kinases phosphorylate substrates
cyclins/CDKs
Lect.4
Intro to Biotech
Lect.4
G2-M transition
Rb = tumor suppressor
- Phosphorylation inactivates
- Rb
E2F initiates DNA
replication
Rb inactivated
by
CyclinE+Cdk2
CyclinD+Cdk4
Rb
E2F
Rb
E2F
G1-S
Transition
Intro to Biotech
1. Replication
Lect.4
G1-S-G2-Mitosis
I
separase
Cyclin-CDK
Activates
APC
cohesin
MTOC
(centrosome)
Centromere
&
kinetochore
T
Centriole
No homologous
pairing!
3. Cytokinesis
haploid
diploid