Yasko Methylation Pathway

Content and diagrams may not be reproduced without express permission from NRI

glycine

Thymidine
synthesis
Purines
THF

5. 10
Methylene THF
Tryptophan
Arginine

Ornithine

AMMONIA

Citrulline + NO

Microglial
Activation

glycine

methylation

adenosine

Homocysteine

5 Methyl
THF

BH2

DMG

Methionine
Cycle SAH

Folate
Cycle

cystathionine
Serotonin

Dopamine
Cysteine + , -ketobutyrate

NorEp
HIAA

taurine

Peroxynitrite

Super Oxide

TMG

2 BH4

Urea
Cycle

Neuronal
Damage

serine

BH4
Cycle

1 BH4

UREA

Creatine

Creatinine

SAMe

Tyrosine

BH4

Guanido AC

Methionine

dUMP

0 BH4

The four cycles that make up the Methylation

Cycle. This first diagram shows the pathways and
the biochemical compounds that are a part of
these cycles.

HVA
VMA

glutathione

DNA, RNA
Protein, lipids

Yasko Methylation Pathway

Content and diagrams may not be reproduced without express permission from NRI

Purines
Methionine

dUMP
The second diagram layers on the location of the
genes in the nutrigenomic test to show where the
possible locations of SNPs are in these biochemical
pathways. The location of the where these genes
act on these pathways are in color.

SHMT
Tryptophan
Arginine

Ornithine

NOS
AMMONIA

Urea
Cycle
Citrulline + NO
Neuronal
Damage

Microglial
Activation

serine

MTR

MTRR

GST
SOD

BHMT
Methionine
Cycle SAH

methylation

adenosine

MTHFR

AHCY
Homocysteine

5 Methyl
THF

CBS
cystathionine

Serotonin

Dopamine

MAO A

MAO B

HIAA

COMT

Cysteine + , -ketobutyrate

NorEp
taurine

COMT

Peroxynitrite

Super Oxide

DMG

TMG

Folate
Cycle

BH2

HVA
VMA

Creatinine

SAMe

glycine

BH4
CycleDHPR

Guanido AC
Creatine

2 BH4

UREA

Tyrosine

BH4

MAT

THF

5. 10
Methylene THF

1 BH4

glycine

Thymidine
synthesis

0 BH4

The four cycles that make up the Methylation

Cycle. This first diagram shows the pathways and
the biochemical compounds that are a part of
these cycles.

glutathione

DNA, RNA
Protein, lipids

Yasko Methylation Pathway

Content and diagrams may not be reproduced without express permission from NRI

Methionine

dUMP
The second diagram layers on the location of the
genes in the nutrigenomic test to show where the
possible locations of SNPs are in these biochemical
pathways. The location of the where these genes
act on these pathways are in color.
The products of the genes often require what are
called cofactors which are helpers that aid the
gene in their function. The cofactors are noted in
purple circles.

ATP

Mg

SHMT
Tryptophan
Arginine

Ornithine

NOS
UREA

AMMONIA

Urea
Cycle
Citrulline + NO
Neuronal
Damage

Microglial
Activation

Tyrosine

BH4
CycleDHPR

GST
SOD

Guanido AC

serine

MTR

MTHFR

Zn
B12

heme

DMG

TMG

MTRR

BHMT Zn
Methionine
Cycle SAH

methylation

adenosine

ATP

AHCY
Homocysteine

5 Methyl
THF

BH2

heme

CBS

B6

cystathionine
Serotonin

Dopamine

MAO A

MAO B

HIAA

COMT

B6

Cysteine + , -ketobutyrate

NorEp
taurine

COMT
HVA
VMA

Creatinine

SAMe

Folate
NADH B2
Cycle

heme

Peroxynitrite

Super Oxide

ATP

Creatine

glycine

BH4

MATMg

THF

5. 10
Methylene THF

2 BH4

Purines

1 BH4

glycine

Thymidine
synthesis

0 BH4

The four cycles that make up the Methylation

Cycle. This first diagram shows the pathways and
the biochemical compounds that are a part of
these cycles.

glutathione

DNA, RNA
Protein, lipids

Yasko Methylation Pathway

Content and diagrams may not be reproduced without express permission from NRI

Nucleotides

The second diagram layers on the location of the

genes in the nutrigenomic test to show where the
possible locations of SNPs are in these biochemical
pathways. The location of the where these genes
act on these pathways are in color.
The products of the genes often require what are
called cofactors which are helpers that aid the
gene in their function. The cofactors are noted in
purple circles.
There are places where nutritional support can be
added to feed into these pathways. This helps to
get around blocks due to malfunctions in the blue
boxed genes. The places and names of the
supplements that can be added to bypass
mutations and where they can feed in to help with
these pathways are in green.

5 Formyl
THF

ATP

Mg

SHMT

Arginine

Ornithine

NOS
UREA

AMMONIA

Urea
Cycle
Citrulline + NO
Neuronal
Damage

Microglial
Activation

Tyrosine

BH4
CycleDHPR

MAO A

MAO B

GST
SOD

B12

MTRR
heme

DMG

TMG

BHMT Zn
Methionine
Cycle SAH

Creatinine

methylation

DNA, RNA
Protein, lipids

adenosine

ATP

AHCY

choline

Homocysteine
heme

CBS

DHA
B6

PC

cystathionine

5 Methyl
THF

B6

PE

Cysteine + , -ketobutyrate

NorEp

COMT

taurine

COMT

Peroxynitrite

Super Oxide

serine

MTR

MTHFR

BH2

Dopamine

Guanido AC

Zn

5 Methyl
THF

Serotonin

ATP

SAMe

Folate
NADH B2
Cycle

heme

HIAA

Methionine

MATMg

SAMe

Creatine

glycine

BH4

glycine

THF

5. 10
Methylene THF

Tryptophan

Methionine

B12

dUMP

2 BH4

Purines

1 BH4

Dopamine
IGF

Thymidine
synthesis

0 BH4

The four cycles that make up the Methylation

Cycle. This first diagram shows the pathways and
the biochemical compounds that are a part of
these cycles.

HVA
VMA

glutathione

PS

Yasko Methylation Pathway

Content and diagrams may not be reproduced without express permission from NRI

Nucleotides

4
5

dUMP
The second diagram layers on the location of the
genes in the nutrigenomic test to show where the
possible locations of SNPs are in these biochemical
pathways. The location of the where these genes
act on these pathways are in color.
The products of the genes often require what are
called cofactors which are helpers that aid the
gene in their function. The cofactors are noted in
purple circles.
There are places where nutritional support can be
added to feed into these pathways. This helps to
get around blocks due to malfunctions in the blue
boxed genes. The places and names of the
supplements that can be added to bypass
mutations and where they can feed in to help with
these pathways are in green.

5 Formyl
THF

ATP

Mg

SHMT
Tryptophan

Arginine

Ornithine

UREA

AMMONIA

Microglial
Activation

B12

Methionine

serine

MTR

MTHFR

BH2

MAO A

MAO B

HIAA

COMT

B12

Super Oxide

GST
SOD

DMG

TMG

MTRR

BHMT Zn
Methionine
LEAD
Cycle SAH

ATP

Creatinine

SAH

methylation

AHCY

DNA, RNA
Protein, lipids

choline

Homocysteine
LEAD

heme

CBS

DHA
B6

PC

cystathionine

5 Methyl
THF

B6

PE

Cysteine + , -ketobutyrate

NorEp
taurine

SAH

COMT

Peroxynitrite

Guanido AC

adenosine

5 Methyl
THF

Dopamine

ATP

Zn

heme

Folate
NADH B2
Cycle

heme

Serotonin

MATMg

SAMe

SAMe

LEAD

Citrulline + NO
Neuronal
Damage

glycine

Creatine

glycine

BH4
NOS ALUM
CycleDHPR
Urea
Cycle

Toxic metals can inhibit steps in these pathways

even if there are not blocks due to mutations. Also
products from the pathway can inhibit other reactions in the pathway. The locations of where the
pathways are inhibited are noted in red.

Tyrosine

BH4

Methionine

THF

5. 10
Methylene THF

2 BH4

LEAD
ALUM
MERCURY

Purines

1 BH4

Dopamine
IGF

Thymidine
synthesis

0 BH4

The four cycles that make up the Methylation

Cycle. This first diagram shows the pathways and
the biochemical compounds that are a part of
these cycles.

HVA
VMA

SAH

glutathione

PS

Yasko Methylation Pathway

Content and diagrams may not be reproduced without express permission from NRI

Nucleotides

4
5
6

dUMP
The second diagram layers on the location of the
genes in the nutrigenomic test to show where the
possible locations of SNPs are in these biochemical
pathways. The location of the where these genes
act on these pathways are in color.
The products of the genes often require what are
called cofactors which are helpers that aid the
gene in their function. The cofactors are noted in
purple circles.
There are places where nutritional support can be
added to feed into these pathways. This helps to
get around blocks due to malfunctions in the blue
boxed genes. The places and names of the
supplements that can be added to bypass
mutations and where they can feed in to help with
these pathways are in green.

5 Formyl
THF

Mg

SHMT

Arginine

Ornithine

AMMONIA

Citrulline + NO

Microglial
Activation

BH2

MTHFR
A1298C
MTHFR
C677T

Dopamine

MAO A

MAO B

HIAA

COMT

SOD

ATP

5 Methyl
THF

ATP

Guanido AC

B12

DMG

TMG

MTRR

BHMT Zn
Methionine
LEAD
Cycle SAH

Creatinine

SAH

methylation

DNA, RNA
Protein, lipids

adenosine

AHCY

MTR &
MTRR

choline

Homocysteine
LEAD

CBS
C699T
mutation

heme

CBS

cystathionine
B6

DHA
B6

PC
CBS
other
mutations

PE

Cysteine + , -ketobutyrate
taurine

SAH

COMT
HVA
VMA
COMT ++
V158M

MATMg

Zn

NorEp

Super Oxide

GST

Methionine

heme

5 Methyl
THF

Peroxynitrite

SOD
mutations

serine

MTR

MTHFR

Serotonin

B12

SAMe

SAMe

Folate
NADH B2
Cycle

LEAD

Urea
Cycle

Neuronal
Damage

heme

glycine

Creatine

glycine

BH4
NOS ALUM
CycleDHPR

NOS
mutations

UREA

Tyrosine

BH4

Methionine

THF

5. 10
Methylene THF

Tryptophan

Toxic metals can inhibit steps in these pathways

even if there are not blocks due to mutations. Also
products from the pathway can inhibit other reactions in the pathway. The locations of where the
pathways are inhibited are noted in red.
The actual SNPs, or mutations in the genes are
noted in pink. Recall that the genes in this pathway
that are looked at by nutrigenomic testing are in
blue boxes. The pink boxes show where the
mutations in these genes occur thus affecting the
position in the cycle where they are located.

ATP

2 BH4

LEAD
ALUM
MERCURY

Purines

1 BH4

Dopamine
IGF

Thymidine
synthesis

0 BH4

The four cycles that make up the Methylation

Cycle. This first diagram shows the pathways and
the biochemical compounds that are a part of
these cycles.

SAH

glutathione

PS