44 TIMBANG, FRANCES PATRICIA D.

2A PH
NAME OF DEFECT

DEFINITION OF
DEFECT

ILLUSTRATION OF DEFECT

REASON OF
THE DEFECT

REMEDY OF
THE DEFECT

1. Chipping/Erosio
n

Increased
brittleness in the
tablet

High degree of
attrition
associated with
the coating
process like
excessive use of
fillers and
pigments

Increase
hardness of the
film by
increasing the
molecular weight
grade of
polymer.

2. Sticking

Involves sticking
of tablets with
each other and
with pan walls.

Higher rate of
application of
coating solution
and inefficient
drying

3. Roughness

Involves presence
of previously
dried sprayed
coating solution
droplets into the
core.

Drying of coating
solution before
reaching surface
of tablet during
spraying

Use optimum
and efficient
drying
conditions.
Increase the inlet
air temperature.
Moving the
nozzle closer
enough;
Reducing the
degree of
atomization.

4. Cracking

Cracking occurs
when the internal
stress exceeds
the tensile
strength of
tablets.

Absorption of
moisture

Adjusting the
coating solution
concentration

5. Capping

Complete/partial
separation of the
upper/lower
surface of the
tablet horizontally

Air is entrapped
in between the
two punches;
improperly dried
granules

Compress the
tablet material at
higher
temperature

6. Bridging/Hazing

Occurs in tablets
consisting in
monogram or
bisection

Too much filling

and thereby
narrowing;
Improper
application of the
tablet
solution/poor
design of the
tablet embossing

Control of
spraying of
normal solution,
concentration of
coating material

7. Blistering

Contains an unsmooth coated

surface with a
number of
uneven spots
called blisters.

Effect of
temperature on
the strength,
elasticity and
adhesion of the
coat

Use mild drying

solution

8. Soft Tablets

The condition
where tablets are
susceptible to
hydrolysis

Lack of drying
time, Improper
storage

Application of
low compaction
nature

9. Lamination

Air entrapment
between layers of
tablet

Low levels of
binding agent

Change in the
method of
granulation

10.Print defect

Letters are
designed in
uneven surface or
layer

Punches having
rough surface

Proper blending
of tablet powder