Professional Documents
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flow diagrams, the hazard analysis, the CCP's identified, Critical Limits, Monitoring System,
Corrective Actions, Recordkeeping Procedures, and Verification Procedures.
HACCP
HACCP
1
Hazard
HACCP
HACCP
(CCP)
,
HACCP
CCP
CCP
CCP
(CL) /
CCP
(AW),
pH,
CCP
4-
HACCP
HACCP
HACCP
HACCP
,
CCP
Recordkeeping
HACCP
HACCP
HACCP,
CCP
Recordkeeping,
HACCP
HACCP
(GMP)
HACCP
(SSOP
GMP
A GMP is a system for ensuring that products are consistently produced and controlled
according to quality standards. It is designed to minimize the risks involved in any
pharmaceutical production that cannot be eliminated through testing the final product.
GMP
GMP
GHP
The Governor's Honors Program (GHP) is a prestigious six week summer instructional
program designed to provide intellectually gifted and artistically talented high school students
challenging and enriching educational opportunities not usually available during the regular
school year.
GHP
(GHP)
FSIS
The Food Safety and Inspection Service (FSIS) is the public health agency in the U.S.
Department of Agriculture responsible for ensuring that the nation's commercial supply of
meat, poultry, and egg products is safe, wholesome, and correctly labeled and packaged.
FSIS
(FSIS)
SSOP
An SSOP is a written procedure that explains exactly how a certain cleaning task is
completed. These procedures may vary from farm to farm. The purpose of the SSOP is to
provide enough detail so employees can perform the task correctly by reading the procedure
without any additional instruction.
SSOP
SSOP
SSOP
Gas chromatography, is a common type of chromatography used in analytical chemistry for
separating and analyzing compounds that can be vaporized without decomposition.
chromatography chromatography
vaporized
decomposition
What
is
Gas
Chromatography?
Chromatography is the separation of a mixture of compounds (solutes) into separate
components. By separating the sample into individual components, it is easier to
identify (qualitate) and measure the amount (quantitate) of the various sample
components. There are numerous chromatographic techniques and corresponding
instruments. Gas chromatography (GC) is one of these techniques. It is estimated
that 10-20% of the known compounds can be analyzed by GC. To be suitable for GC
analysis, a compound must have sufficient volatility and thermal stability. If all or
some of a compounds molecules are in the gas or vapor phase at 400-450C or
below, and they do not decompose at these temperatures, the compound can
probably be analyzed by GC.
The main parts of a basic GC system are shown in Figure 1. One or more high purity
gases are supplied to the GC. One of the gases (called the carrier gas) flows into the
injector, through the column and then into the detector. A sample is introduced into
the injector usually with a syringe or an exterior sampling device. The injector is
usually heated to 150-250C which causes the volatile sample solutes to vaporize.
The vaporized solutes are transported into the column by the carrier gas. The column
is maintained in a temperature controlled oven. The solutes travel through the
column at a rate primarily determined by their physical properties, and the
temperature and composition of the column. The various solutes travel through the
column at different rates. The fastest moving solute exits (elutes) the column first
then is followed by the remaining solutes in corresponding order. As each solute
elutes from the column, it enters the heated detector. An electronic signal is
generated upon interaction of the solute with the detector. The size of the signal is
recorded by a data system and is plotted against elapsed time to produce a
chromatogram.
Chromatography
Chromatography ()
()
chromatographic
chromatography
(quantitate)
(GC)
10-20% GC
GC,
400-450 C
GC
GC 1
GC
)
heated
150-250
vaporize
vaporized
oven
(elutes)
elutes
chromatogram