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    Bleeding Disorders

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    GovindSoni
    This document discusses different types of bleeding disorders. It classifies disorders into those involving platelets or coagulation factors. Platelet disorders can decrease platelet numbers through conditions like thrombocytopenia, or decrease platelet function. Thrombocytopenia is classified based on pathogenesis and can cause bleeding symptoms. Coagulation disorders involve deficiencies in specific clotting factors, such as hemophilia A which is a Factor VIII deficiency. Hemophilia causes bleeding into joints and symptoms are diagnosed through prolonged aPTT. Idiopathic thrombocytopenic purpura (ITP) is an autoimmune condition that can be acute and self-limiting, especially in children after viral infections, or chronic.

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    Bleeding Disorders

    Uploaded by

    GovindSoni
    84 views15 pages
    This document discusses different types of bleeding disorders. It classifies disorders into those involving platelets or coagulation factors. Platelet disorders can decrease platelet numbers through conditions like thrombocytopenia, or decrease platelet function. Thrombocytopenia is classified based on pathogenesis and can cause bleeding symptoms. Coagulation disorders involve deficiencies in specific clotting factors, such as hemophilia A which is a Factor VIII deficiency. Hemophilia causes bleeding into joints and symptoms are diagnosed through prolonged aPTT. Idiopathic thrombocytopenic purpura (ITP) is an autoimmune condition that can be acute and self-limiting, especially in children after viral infections, or chronic.

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    This document discusses different types of bleeding disorders. It classifies disorders into those involving platelets or coagulation factors. Platelet disorders can decrease platelet numbers through conditions like thrombocytopenia, or decrease platelet function. Thrombocytopenia is classified based on pathogenesis and can cause bleeding symptoms. Coagulation disorders involve deficiencies in specific clotting factors, such as hemophilia A which is a Factor VIII deficiency. Hemophilia causes bleeding into joints and symptoms are diagnosed through prolonged aPTT. Idiopathic thrombocytopenic purpura (ITP) is an autoimmune condition that can be acute and self-limiting, especially in children after viral infections, or chronic.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as pptx, pdf, or txt
    84 views15 pages

    Bleeding Disorders

    Uploaded by

    GovindSoni
    This document discusses different types of bleeding disorders. It classifies disorders into those involving platelets or coagulation factors. Platelet disorders can decrease platelet numbers through conditions like thrombocytopenia, or decrease platelet function. Thrombocytopenia is classified based on pathogenesis and can cause bleeding symptoms. Coagulation disorders involve deficiencies in specific clotting factors, such as hemophilia A which is a Factor VIII deficiency. Hemophilia causes bleeding into joints and symptoms are diagnosed through prolonged aPTT. Idiopathic thrombocytopenic purpura (ITP) is an autoimmune condition that can be acute and self-limiting, especially in children after viral infections, or chronic.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    Download as pptx, pdf, or txt
    of 15

    Bleeding Disorders

    Classification

    Disorders of primary haemostasis ( platelet disorders )

    Disorders of coagulation.

    Disorders

    of primary haemostatsis

    Decrease in platelet number thrombocytopenia

    Decrease in platelet function

    THROMBOCYTOPENIA

    Normal platelet count- 1.5-4lakhs/cumm

    80,000/cumm no clinical defect

    40,000/cumm- post traumatic bleeding

    < 20,000/cumm-spontaneous haemorrhage

    <10,000/cumm- intracranial bleeding

    Classification based on pathogenesis

    Platelet Production failure aplastic anemia, marrow


    infiltration, megaloblastic anemia

    Increased platelet destruction ITP, drug


    induced,infections(HIV), DIC,TTP,HUS.

    Platelet sequestration - hyperslenism

    Dilutional

    Clinical

    Features

    Petichiae

    purpura

    ecchymosis

    mucosal bleeding,joint bleeding,

    muscle hematoma

    bleeding after surgery.

    Basic

    Investigations

    Platelet count : 1.5 lakh to 4 lakh

    Bleeding time : 2 to 8 min

    Clotting time : 4 to 10 min

    Protrombin time: 10 to 15 seconds

    Activated partial thromboplastin time: 30 to 40 seconds

    HEMOPHILIA

    Disease caused due to defect in the clotting factors.

    Two types Hemophilia A and B

    Hemophilia A Factor VIII

    Hemophilia B Factor IX

    Both are identical clinically , they differ only in the type of


    factor which is deficient.

    Sex linked inherited defect

    Clinical Features :
    Spontaneous

    Bleeding

    haemorrhage

    into the joints ( hemarthrosis )

    Repeated

    attacks of joint bleeding.

    Platelet

    PT

    count normal

    normal

    APTT

    prolonged

    Treatment : Replacement of clotting factor

    ITP
    Acute

    1.Spontaneous remitting type

    2.Children

    3.Follows viral(measles,rubella, EBV)

    infection

    Chronic

    1. Idiopathic or secondary

    2.All ages

    3.CLL, Lymphoma,SLE, RA

    Clinical

    features :

    Epistaxis
    Easy

    bruising

    Gum

    bleeding

    Hematuria

    Thank you

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