Multiscale data integration

into a structure/function model

of H/ACA guide RNAs in Archaea
keywords: structural & RNA biology, phylogeny, transcriptomics,
bioinformatics

Fabrice Leclerc
IGM - Orsay
fabrice.leclerc@igmors.u-psud.fr

Outline

H/ACA guide RNAs: structure(s) & old/new

function(s) (Eukaryotes)
Archaea: H/ACA (Euryarchaea + Crenarchaea) &
H/ACA-like (Crenarchaea): variations on the same
theme ?
Alternative function(s) in Archaea ?