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Skeletalmusclelabreport
Skeletalmusclelabreport
SkeletalMuscleLabReport
DueNov23rd
Skeletalmuscleconnectstotheskeleton,toformpartofthemechanicalsystem,giving
theabilitytomovelimbsthroughouttheentirebody.In1864Kuhnediscoveredthemyosin
proteinandthattheskeletalmuscleismadeupofhundreds,oreventhousandsofmusclefibers
bundledtogetherandwrappedinaconnectivetissuecovering.Musclecontractionsofthose
thousandsofmusclefiberswerestudiedbyfourmajorscientistsAndrewF.Huxley,rolf
Niedergerke,HughHuxley,andJeanHansonin1954theyfoundthatATPcausedactinand
myosintoslideacrosseachotherastheskeletalmusclecontractionoccurred.AngeloMossoin
thelate1800sworkedwithphysiologistsWilhelmLudwig,DuBoisReymond,hugoKronecker,
andEtienneMareytoconductresearchonmusclefatigueusingmuscletracings.Applying
knowledgeofskeletalmusclestructure,contraction,fatiguethefollowinglabswereconducted
showingtheeffectoftheATPontherabbitfibersandthefatiguecausedbycontinuousand
repetitivemusclecontractions
Part1.
SkeletalMuscleStructure:
Figure1:Drawingofthelayersoftheskeletalmusclestructurestartingfromthebonetothe
myofibrilstoillustratethescaleofmusclesystem
Part2.MuscleContraction
MuscleFiber
Lengthsinmm
BeforeATPLength
AfterATPLength
BeforeATPWidth
AfterATPWidth
125
110
10
125
90
15
20
135
120
12
16
123
110
11
Averages
127
107.5
11
14.25
PercentContraction
84.64
129.54
Theskeletalmuscleisoneofthethreemajormusclesystems.Themusclesgotshorterwhen
ATPwasaddedbecausetheATPsimulatesacontractionofthemyosinheadsattachingtothe
actinformingabridgethatpullsthefilamentinwardsofthesarcomerethuscausingittoshorten.
Part3.MuscleFatigue
Thedataintherepetitiveandcontinuousgriptestshowsthatmusclesstarttoshowfatiguethe
longeryouperformthetest.Whenyourbrainsendsasignaltoexertmoreforcetotheobject
themusclesbegintoworkharderagain.Thefasttwitchmusclesfatigueaslacticacid
accumulatedandastheATPandbiochemicalstoregenerateATParedepleted.Therefore
grippingtheprobeweakerastimegoesonuntilthebrainremindsthemuscleitcangripharder.