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wibisono

CONGENITAL
METABOLI
C

INFECTIO
N
MECHANIC
AL

NEOPLASM

NORMAL
NUTRITION

HORMONAL

CHEMICA
L

BONE INJURY

BONE INFLAMMATION

HEALING
PROCESS :

GRANULATIONTISSUE
SQUESTER
INFLAMMATION
OSTEOID FORMATION

RECOVERY

REMODELLIN
G
NEOPLAS
M

Degenerative

ABNORMAL WEARING
OF THE CARTILAGE
OLDER
PERSONS
DISEASES

AQCUIRED

LOCAL
SYSTEMI
C

DEGENERATIVE OF THE
BONE

DEGENERATIVE JOINT
DISEASES
DEGENERATIVE
BONE DISEASES
With
inflammation
OA
osteoporesis
No
inflammation

POROTI
C
There are 3 common forms of OA :
1.It causes bony enlargement of the finger
joints
2.It involves Spine
3. It involves the weight bearing joints

An excessive growth of bone

INFECTION
HORMONAL
METABOLISM
NEOPLASTIC

Sclerosis

Hardening of bone

An overgrowth of
bone
OSTEOPHYTE

Cartilage does not have a

blood supply and receives
its oxygen and nutrition
from the surrounding joint
fluid by diffusion

SUBCHONDRA
L BONE

NARROWING OF
THE JOINT SPACE

Subchondral
cysts:
Ussually caused by
degenerative changes
in the stressed bone

BONE TUMORS OF
MISCELLAMOUS TYPE
(UNCERTAIN LINEAGE)

Fibrous
lesion

-Fibros dysplasia

-osteofbrous
dysplasia

Cystic lesion
*Aneurysmal bone cyst

*Solitary bone cyst

*Intraosseous ganglion
*Langerhans
Cell
histiocytosis
*Erdheim-Chester disease

FIBROUS
DYSPLASIA

MUSCLE

ATROPHY

HYPERTROPHY

NEUROGENIC
ATROPHY

MYASTHENIA GRAVIS:
A defect in the action
acetylcholine

of

INHERITED
MYOPATHIES

ACQUIRED
MYOPATHIES

MUSCULAR DYSTROPHY

DUCHENE MUSCULAR
DYSTROPHY
Muscle damage and
weakness

Polimyositis
Dermatomyositis
Ect

Lipid
metabolis
m

Glycogen
storage
Periodic
paralysis :
Hypohyperkalemia

TUMOURS IN
BONE
OSTEOID OSTEOMA :

A SMALL FOCUS OF NEWLY FORMED

IRREGULAR TRABECULAE OF OSTEOID OR
POORLY CALCIFIED WOVEN BONE IN
HIGHLY VASCULAR STROMA
(OSTEOBLASTIC ACTIVITY)

GIANT CELL TUMOR

It is destructive the end of long bone.
Pathological fracture is common

benign

CHONDROBLASTOMA

The most chondroblastoma occur in the

epiphyses of long bone.
Mic.: The cellular component consists of
mononuclear cells and multinucleated
giant cells.
The charateristic features are Chicken wire
calicification,Fibrochondroid matrix and
nuclear grooves

CHONDROMA

OSTEOMA

OSTEOID OSTEOMA

EWINGS SARCOMA

MALIGNANT