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Seward Scisef
Seward Scisef
Problem Statement
Review of Literature
McKee, A. C., e.t. all. (2009). Chronic
Traumatic Encephalopathy in Athletes:
Progressive Tauopathy following
Repetitive Head Injury. Journal of
Neuropathology and Experimental
Neurology, 68(7), 709735.
Mckee, A. (n.d.). (2012). The Spectrum of
Disease in Chronic Traumatic
Encephalopathy. Brain A Journal of
Neurology, 1-22. Retrieved October 22,
2014
Small, G., e.t. all. (n.d.). PET Scanning of
Brain Tau in Retired National Football
League Players: Preliminary Findings.
The American Journal of Geriatric
Psychiatry, 21(2), 138-144. Retrieved
January 31, 2015
Gavett, B. E., e.t. all (2011). Chronic
Traumatic Encephalopathy: A Potential
Late Effect of Sport-Related Concussive
and Subconcussive Head Trauma. Clinics
in Sports Medicine, 30(1), 179.
Isabelle Seward
isabelleseward@gmail.com
Ridgefield High School Science
Research
Proposed Methodology
Concussion history of high school, collegiate, professional and retired American
Football players will be observed to determine correlations between total number of
reported injuries in the subjects life.
PET (positron emission tomography) brain scans of high-school, collegiate, and
professional level football athletes in addition to a retired player, all demonstrating
Stage I severity of CTE will be compared to each other and a control to examine p-tau
build up patterns.*
*Alternate approaches may include the ultization of CT or MRI Scan in place of the PET Scan
which would allow observation of how the brain structure is effected by the disease as opposed to
just chemical activity within it.
Proposed Results
Expected results should show similarities of
entanglement concentrated mostly around
vessels or at the depths of the sulci in the
cerebral cortex. Limited p-tau
concentrations may be found in the locus
coeruleus. In addition to the similarities of
tau pathology in the Stage I samples, the
demographic factors of concussion history
should point to be closely similar despite
age of player or mean numbers of years
playing football.
Future Implications
Based on the results of correlations
between both the players demographic
and PET findings, numerous implications
may be applied in terms of diagnosis and
athlete safety