Diuretics: Common Diuretics (Thiazides, Loop, K-Retaining)

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DIURETICS

Common Diuretics (Thiazides, Loop, K-retaining):


Members
Mechanism of action:
1) Site of action of the diuretic
2) How the diuretic reaches its site of action
3) The main diuretic target
a. Thiazides
b. Loop
c. K-retaining
4) Additional non-diuretic actions
Adverse effects:
1) Effects on blood chemistry:
a. Water
b. Electrolytes:
i. Sodium
ii. Potassium & Magnesium
iii. Calcium
c. Acid base balance
d. Glucose
e. Uric acid
2) General adverse effects
3) Special adverse effects
Indications:
1) Oedema
a. Heart failure and acute pulmonary edema
b. Hepatic edema
c. Nephrotic edema
d. Acute renal failure
e. Refractory edema
f. Other types of edema
Practical points about edema
2) Hypertension
3) Additional indications
Administration
Rare Diuretics:
1) Osmotic diuretics
2) Carbonic Anhydrase Inhibitors

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