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80217784 การคำนวณทางเภสัช
80217784 การคำนวณทางเภสัช
80217784 การคำนวณทางเภสัช
4850320
17
/
: ,
Anthropometry
Organs function :
/
mmol mEq
o electrolyte, -
g, mmol, mEq
sodium 100
mmol/day 2.4 g sodium 6 g sodium
chloride
(mEq)
mEq =
=
ion
17
. 4850320
(mEq/L)
mEq/L
valence ion
(g/MW) x (1000/V) x
mcg/kg/min ud/min
0.3x60 mcg/min
18 mcg/min
250 ml
NE
= 8 x 103 mcg
1 ml NE = 8 x 103 /250
ud/min
ml/hr
(60/60)
(1/1)
18 mcg/min
1 NE 18
60 NE 18 x 60
mcg
mcg
mcg
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NE
. 18 x 60
18 x 60 mcg
8 x 10 /250
ml
ml
Dose(mcg/min) x 60 x ml
3
x 10
(Dose calculation)
(Usual dose) :
tetracycline 250 500 mg
4
o 15 kg
375 750 mg/day
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o 250 mg amoxycillin/ 5 ml
1 3
o / : mg/, mg/
o : mg/ml, %W/V, mg/vial
o % : / >>
%W/W
Allegation method
Allegation method :
%
:
1.
( A)
2. ( B)
3.
( C)
4. 3
1:10,000
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17
a. Epinephrine = ?? mg/ml
b. 50 kg epinephrine
1:10,000 = ?? ml
c. . 1:1,000 Epinephrine
1:10,000 ??
0.1 mg/ml
mg Epinephrine
1:10,000 5 ml
c. . 1:10,000 10
Epinephrine 1:10,000
1 + diluent 10 diluent 9
allegation method
= 0.01%
Epinephrine 1:1,000 0.1%
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0.0%)
0.0%
0.01%)
(column A)
(column C)
>> : Epinephrine
1:1,000 1 NSS 9
, , TPN
drop
drop/min drop factor (drops/ml)
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o Macrodrip = 10 20 drops/ml
o Microdrip/minidrip = 60 drops/ml ( pediatric sets)
o Blood sets = 10 drops/ml
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: < 50 kg
body surface area :
nomogram
o Mostellers equation ()
2
(kg)
(cm) x
3600
o Frieds rule ( 2 )
Infants dose
[()/150] x
[BSA(m )/1.73] x
o surface area
Childs dose
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. 4850320
o Youngs rule (1 12 )
Childs dose
[( )/( + 12)] x
o Clarks rule ()
Childs dose
[ (lb)/150] x
(Anthropometry)
Ideal body weight (IBW) kg
creatinine clearance aminoglycoside
o
IBW (kg)
5 )
IBW (kg) =
5 )
o 1 18
50 + (2.3 x
45.5 + (2.3 x
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IBW (kg)
[( )2 x
%IBW
[(kg)/IBW] x 100
1.65]/1000
Adjusted BW
IBW + 0.4(W-IBW)
renal function
:
>> Stable renal function : serum creatinine
( 0.5
0.7 mg/dL/day)
creatinine
(ml/min)
24 hr urine Cr collection
UrineCr x V
1440 x SCr
o (> 18 ) : Cockroft & Gault equation
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ClCr()
(ml/min)
ClCr()
0.85 x
BSA ml/min/1.73 m
ClCr()
ClCr()
98 0.8( 20) x
SCr (mg/dL)
1.73
0.85 x
1.73
o (> 6 ) (< 21 ) : Schwartz Brion &
Spitzer equation
ClCr
(K x H/Scr) x (BSA/1.73)
(cm)
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ClCr
: Low birth
m)
weight < 1
= 0.33
= 0.45
0.55
: 13 21
= 0.55
: 13 21
= 0.70