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    Amphetamine Synthetic Routes

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    housemouse
    This document outlines six methods for synthesizing amphetamine. Method 1 involves a Leuckart reaction, Method 2 uses a Friedel–Crafts alkylation, Method 3 is a Ritter synthesis, Method 4 uses Hofmann and Curtius rearrangements, Method 5 employs a Knoevenagel condensation, and Method 6 synthesizes amphetamine from phenylacetone and ammonia.

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    Amphetamine Synthetic Routes

    Uploaded by

    housemouse
    1K views2 pages
    This document outlines six methods for synthesizing amphetamine. Method 1 involves a Leuckart reaction, Method 2 uses a Friedel–Crafts alkylation, Method 3 is a Ritter synthesis, Method 4 uses Hofmann and Curtius rearrangements, Method 5 employs a Knoevenagel condensation, and Method 6 synthesizes amphetamine from phenylacetone and ammonia.

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    Amphetamine Synthetic Routes

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    This document outlines six methods for synthesizing amphetamine. Method 1 involves a Leuckart reaction, Method 2 uses a Friedel–Crafts alkylation, Method 3 is a Ritter synthesis, Method 4 uses Hofmann and Curtius rearrangements, Method 5 employs a Knoevenagel condensation, and Method 6 synthesizes amphetamine from phenylacetone and ammonia.

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    © All Rights Reserved
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    1K views2 pages

    Amphetamine Synthetic Routes

    Uploaded by

    housemouse
    This document outlines six methods for synthesizing amphetamine. Method 1 involves a Leuckart reaction, Method 2 uses a Friedel–Crafts alkylation, Method 3 is a Ritter synthesis, Method 4 uses Hofmann and Curtius rearrangements, Method 5 employs a Knoevenagel condensation, and Method 6 synthesizes amphetamine from phenylacetone and ammonia.

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    Amphetamine synthetic routes

    Method 1: Synthesis by the Leuckart reaction

    Top: Chiral resolution of amphetamine


    Bottom: Stereoselective synthesis of amphetamine

    Method 2: Synthesis by FriedelCrafts alkylation

    Method 3: Ritter synthesis

    Method 4: Synthesis via Hofmann and Curtius rearrangements

    Method 5: Synthesis by Knoevenagel condensation

    Method 6: Synthesis using phenylacetone and ammonia

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