Pharmacy - 4A Members: Boiser, Gaebrelle Anne Cagas, Dianna Feb Davocol, Dahna Laiza Kasid, Sittie Namraida Malabarbas, Albert Masaya, Julyka MALATHION
Chemical Composition: Malaoxon
Mechanism of Toxicity: Malathion is a cholinesterase inhibitor, a diverse family
of chemicals. Upon uptake into the target organism, it binds irreversibly to several, random cysteine residues on the cholinesterase enzyme, with peroxide as the leaving group, the resultant phosphoester group bonds to cholinesterase and denatures proteins. Uses: Pesticide; 0.5% preparation are used for head lice and body lice Toxic Effects: Airways and lungs: Chest tightness and difficulty in breathing Bladder and Kidneys: Increased urination Heart and blood: Low or High Blood Pressure; Slow or Rapid Heart Rate Nervous System: Agitation, Anxiety, Coma, Confusion Antidote: Treatment for malathion poisoning consists of thorough decontamination, cardiorespiratory support and administration of the antidote atropine and pralidoxime. In cases of severe poisoning, diazepam should be administered.